Serological cross-reactivity using a SARS-CoV-2 ELISA test in acute Zika virus infection, Colombia.
Int J Infect Dis
; 101: 191-193, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-799213
ABSTRACT
OBJECTIVES:
We investigated seroreactivity by using a commercial SARS-CoV-2 ELISA test in samples collected from different groups of individuals, including patients diagnosed to have Dengue, Zika, and Chikungunya infection between 2015 and 2019, from an endemic area in the Caribbean Colombian region.METHODS:
A total of 127 sera samples obtained from six different groups of individuals were included in this study Group A patients with confirmed SARS-CoV-2 infection; Group B patients with symptoms suggestive of COVID-19 or asymptomatic contacts with confirmed patients; Group C patients with acute or recent dengue virus infection; Group D patients with acute Zika virus infection; Group E patients with previous Chikungunya virus infection; and Group F individuals with exposure to spotted fever group rickettsiae.RESULTS:
Overall, group A, group B, and group D showed seroreactivity to SARS-CoV-2 in 92%, 75%, and 26% of samples, respectively; furthermore, group C, group E, and group F showed 100% seronegativity.CONCLUSIONS:
We found 26% of serological cross-reactivity in patients with acute Zika virus infection by using a commercial SARS-CoV-2 ELISA test. Further studies are needed to evaluate whether serological cross-reaction is maintained with time in nonacute patients with previous exposure to the Zika virus and its effect in SARS-CoV-2 serosurveys in endemic areas for this arbovirus.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cross Reactions
/
Zika Virus
/
Zika Virus Infection
/
SARS-CoV-2
/
COVID-19
/
Antibodies, Viral
Type of study:
Experimental Studies
/
Observational study
/
Randomized controlled trials
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
/
Middle aged
/
Young adult
Country/Region as subject:
South America
/
Colombia
Language:
English
Journal:
Int J Infect Dis
Journal subject:
Communicable Diseases
Year:
2020
Document Type:
Article
Affiliation country:
J.ijid.2020.09.1451
Similar
MEDLINE
...
LILACS
LIS