Impairment of the cholinergic anti-inflammatory pathway in older subjects with severe COVID-19.

Pomara, Nunzio; Imbimbo, Bruno P

Pomara, Nunzio; Imbimbo, Bruno P.

Pomara N; Geriatric Psychiatry Division, Nathan Kline Institute, 140 Old Orangeburg Rd, Bldg 35, Orangeburg, NY 10962-1157, USA. Electronic address: nunzio.pomara@NKI.rfmh.org.
Imbimbo BP; Research & Development Department, Chiesi Farmaceutici, Largo Francesco Belloli 11/a, 43122 Parma, Italy.

Med Hypotheses ; 144: 110274, 2020 11.

Article in English | MEDLINE | ID: covidwho-799747

Subject(s)

Aging; Alzheimer Disease/immunology; COVID-19/complications; COVID-19/immunology; Dementia/immunology; Inflammation/virology; Acetylcholinesterase/metabolism; Aged; Alzheimer Disease/complications; Brain/immunology; Brain/metabolism; Butyrylcholinesterase/metabolism; Cholinergic Agents/metabolism; Cytokines/blood; Cytokines/metabolism; Dementia/complications; Humans; Immunity, Innate; Neuroimmunomodulation; T-Lymphocytes/immunology

Keywords

Alzheimer's disease; COVID-19; Cholinergic anti-inflammatory pathway (CAP); Immunosenescence

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Aging / Dementia / Alzheimer Disease / COVID-19 / Inflammation Topics: Long Covid Limits: Aged / Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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