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Neutralizing antibody response elicited by SARS-CoV-2 receptor-binding domain.
Huang, Ping-Han; Tsai, Hsiao-Han; Liao, Bo-Hung; Lin, Yi-Ling; Jan, Jia-Tsrong; Tao, Mi-Hua; Chou, Yu-Chi; Hu, Che-Ming Jack; Chen, Hui-Wen.
  • Huang PH; Department of Veterinary Medicine, National Taiwan University, Taipei, Taiwan.
  • Tsai HH; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Liao BH; Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica, Taipei, Taiwan.
  • Lin YL; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Jan JT; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Tao MH; Genomics Research Center, Academia Sinica, Taipei, Taiwan.
  • Chou YC; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
  • Hu CJ; RNAi Core Facility, Academia Sinica, Taipei, Taiwan.
  • Chen HW; Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Hum Vaccin Immunother ; 17(3): 654-655, 2021 03 04.
Article in English | MEDLINE | ID: covidwho-801647
ABSTRACT
A safe and effective vaccine candidate is urgently needed for the ongoing COVID-19 pandemic, caused by SARS-CoV-2. Here we report that recombinant SARS-CoV-2 RBD protein immunization in mice is able to elicit a strong antibody response and potent neutralizing capability as measured using live or pseudotyped SARS-CoV-2 neutralization assays.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Binding / Antibodies, Neutralizing / Protein Domains / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Animals / Humans Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2020.1814098

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Protein Binding / Antibodies, Neutralizing / Protein Domains / SARS-CoV-2 / COVID-19 / Antibodies, Viral Topics: Vaccines Limits: Animals / Humans Language: English Journal: Hum Vaccin Immunother Year: 2021 Document Type: Article Affiliation country: 21645515.2020.1814098