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Possible pharmaceutical applications can be developed from naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids.
Jia, Xian-Hui; Zhao, Huan-Xin; Du, Cheng-Lin; Tang, Wen-Zhao; Wang, Xiao-Jing.
  • Jia XH; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250062 People's Republic of China.
  • Zhao HX; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250062 People's Republic of China.
  • Du CL; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250062 People's Republic of China.
  • Tang WZ; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250062 People's Republic of China.
  • Wang XJ; Institute of Materia Medica, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, 250062 People's Republic of China.
Phytochem Rev ; 20(4): 845-868, 2021.
Article in English | MEDLINE | ID: covidwho-801732
Semantic information from SemMedBD (by NLM)
1. Cisplatin/Doxorubicin/Ifosfamide protocol USES Antineoplastic Agents
Subject
Cisplatin/Doxorubicin/Ifosfamide protocol
Predicate
USES
Object
Antineoplastic Agents
2. Cisplatin/Doxorubicin/Ifosfamide protocol USES Antineoplastic Agents
Subject
Cisplatin/Doxorubicin/Ifosfamide protocol
Predicate
USES
Object
Antineoplastic Agents
ABSTRACT
Naturally occurring phenanthroindolizidine and phenanthroquinolizidine alkaloids (PIAs and PQAs) are two small groups of herbal metabolites sharing a similar pentacyclic structure with a highly oxygenated phenanthrene moiety fused with a saturated or an unsaturated N-heterocycle (indolizidine/quinolizidine moieties). Natural PIAs and PQAs only could be obtained from finite plant families (such as Asclepiadaceae, Lauraceae and Urticaceae families, etc.). Up to date, more than one hundred natural PIAs, while only nine natural PQAs had been described. PIA and PQA analogues have been applied to the development of potent anticancer agents all along because of their excellent cytotoxic activity. However, in the last two decades, other great biological properties, such as anti-inflammatory and antiviral activities were revealed successively by different pharmacological assays. Especially because of their potent antiviral activity against coronavirus (TGEV, SARS CoV and MHV) and tobacco mosaic virus, PIA and PQA analogues have attracted much pharmaceutical attention again, some of them have been used to present interesting targets for total or semi synthesis, and structure-activity relationship (SAR) study for the development of antiviral agents. In this review, natural PIA and PQA analogues obtained in the last two decades with their herbal origins, key spectroscopic characteristics for structural identification, biological activity with possible SARs and application prospects were systematically summarized. We hope this paper can stimulate further investigations on PIA and PQA analogues as an important source for potential drug discovery.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Topics: Traditional medicine Language: English Journal: Phytochem Rev Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Randomized controlled trials Topics: Traditional medicine Language: English Journal: Phytochem Rev Year: 2021 Document Type: Article