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Increased risk of SARS-CoV-2 infection in staff working across different care homes: enhanced CoVID-19 outbreak investigations in London care Homes.
Ladhani, Shamez N; Chow, J Yimmy; Janarthanan, Roshni; Fok, Jonathan; Crawley-Boevey, Emma; Vusirikala, Amoolya; Fernandez, Elena; Perez, Marina Sanchez; Tang, Suzanne; Dun-Campbell, Kate; Wynne-Evans, Edward; Bell, Anita; Patel, Bharat; Amin-Chowdhury, Zahin; Aiano, Felicity; Paranthaman, Karthik; Ma, Thomas; Saavedra-Campos, Maria; Myers, Richard; Ellis, Joanna; Lackenby, Angie; Gopal, Robin; Patel, Monika; Chand, Meera; Brown, Kevin; Hopkins, Susan; Consortium, CoG; Shetty, Nandini; Zambon, Maria; Ramsay, Mary E.
  • Ladhani SN; Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK; Paediatric Infectious Diseases Research Group, St. George's University of London, UK. Electronic address: shamez.ladhani@phe.gov.uk.
  • Chow JY; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Janarthanan R; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Fok J; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Crawley-Boevey E; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Vusirikala A; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Fernandez E; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Perez MS; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Tang S; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Dun-Campbell K; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Wynne-Evans E; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Bell A; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Patel B; London Health Protection team, National Infection Service, Public Health England, London, UK.
  • Amin-Chowdhury Z; Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Aiano F; Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
  • Paranthaman K; Field Service, National Infection Service, Public Health England.
  • Ma T; Field Service, National Infection Service, Public Health England.
  • Saavedra-Campos M; Field Service, National Infection Service, Public Health England.
  • Myers R; Infectious Disease Informatics, Public Health England, London, UK.
  • Ellis J; Virus Reference department, Public Health England, London, UK.
  • Lackenby A; Virus Reference department, Public Health England, London, UK.
  • Gopal R; Virus Reference department, Public Health England, London, UK.
  • Patel M; Virus Reference department, Public Health England, London, UK.
  • Chand M; Antimicrobial Resistance and Hospital Acquired Infection Department, Public Health England, London, UK.
  • Brown K; Virus Reference department, Public Health England, London, UK.
  • Hopkins S; Antimicrobial Resistance and Hospital Acquired Infection Department, Public Health England, London, UK.
  • Consortium C; COVID-19 Genomics UK Consortium (https://www.cogconsortium.uk/).
  • Shetty N; Virus Reference department, Public Health England, London, UK.
  • Zambon M; Virus Reference department, Public Health England, London, UK.
  • Ramsay ME; Immunisation and Countermeasures Division, Public Health England, 61 Colindale Avenue, London NW9 5EQ, UK.
J Infect ; 81(4): 621-624, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-801950
Semantic information from SemMedBD (by NLM)
1. Severe Acute Respiratory Syndrome PROCESS_OF Staff
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Staff
2. Severe Acute Respiratory Syndrome PROCESS_OF Staff
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Staff
ABSTRACT

BACKGROUND:

Care homes have been disproportionately affected by the COVID-19 pandemic and continue to suffer large outbreaks even when community infection rates are declining, thus representing important pockets of transmission. We assessed occupational risk factors for SARS-CoV-2 infection among staff in six care homes experiencing a COVID-19 outbreak during the peak of the pandemic in London, England.

METHODS:

Care home staff were tested for SARS-COV-2 infection by RT-PCR and asked to report any symptoms, their contact with residents and if they worked in different care homes. Whole genome sequencing (WGS) was performed on RT-PCR positive samples.

RESULTS:

In total, 53 (21%) of 254 staff were SARS-CoV-2 positive but only 12/53 (23%) were symptomatic. Among staff working in a single care home, SARS-CoV-2 positivity was 15% (2/13), 16% (7/45) and 18% (30/169) in those reporting no, occasional and regular contact with residents. In contrast, staff working across different care homes (14/27, 52%) had a 3.0-fold (95% CI, 1.9-4.8; P<0.001) higher risk of SARS-CoV-2 positivity than staff working in single care homes (39/227, 17%). WGS identified SARS-CoV-2 clusters involving staff only, including some that included staff working across different care homes.

CONCLUSIONS:

SARS-CoV-2 positivity was significantly higher among staff working across different care homes than those who were working in the same care home. We found local clusters of SARS-CoV-2 infection between staff only, including those with minimal resident contact. Infection control should be extended for all contact, including those between staff, whilst on care home premises.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Occupational Exposure / Coronavirus Infections / Homes for the Aged / Medical Staff / Nursing Homes Type of study: Etiology study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Occupational Exposure / Coronavirus Infections / Homes for the Aged / Medical Staff / Nursing Homes Type of study: Etiology study / Prognostic study / Risk factors Limits: Humans Country/Region as subject: Europa Language: English Journal: J Infect Year: 2020 Document Type: Article