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Eculizumab treatment for renal failure in a pediatric patient with COVID-19.
Mahajan, Ruchi; Lipton, Marissa; Broglie, Larisa; Jain, Namrata Gargee; Uy, Natalie Somera.
  • Mahajan R; Division of Pediatric Nephrology, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, PH 17-102B, New York, NY, 10032, USA.
  • Lipton M; Division of Pediatric Nephrology, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, PH 17-102B, New York, NY, 10032, USA.
  • Broglie L; Division of Pediatric Bone Marrow Transplantation, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, 10032, USA.
  • Jain NG; Division of Pediatric Nephrology, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, PH 17-102B, New York, NY, 10032, USA.
  • Uy NS; Division of Pediatric Nephrology, Columbia University Vagelos College of Physicians and Surgeons, 622 West 168th Street, PH 17-102B, New York, NY, 10032, USA. nsu1@cumc.columbia.edu.
J Nephrol ; 33(6): 1373-1376, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-802152
ABSTRACT
While there are increasing reports of acute kidney injury among hospitalized adults with COVID-19, there is still limited information on renal complications associated with COVID-19 in children. The cause of kidney involvement in COVID-19 is likely multifactorial, and appears to involve a complex process, including complement dysregulation and thrombotic microangiopathy. We present a pediatric case of COVID-19 and renal failure due to thombotic microangiopathy, successfully treated with eculizumab.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Dialysis / Antibodies, Monoclonal, Humanized / SARS-CoV-2 / COVID-19 / Kidney Failure, Chronic Type of study: Case report / Observational study Limits: Adolescent / Female / Humans Language: English Journal: J Nephrol Journal subject: Nephrology Year: 2020 Document Type: Article Affiliation country: S40620-020-00858-2

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Renal Dialysis / Antibodies, Monoclonal, Humanized / SARS-CoV-2 / COVID-19 / Kidney Failure, Chronic Type of study: Case report / Observational study Limits: Adolescent / Female / Humans Language: English Journal: J Nephrol Journal subject: Nephrology Year: 2020 Document Type: Article Affiliation country: S40620-020-00858-2