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COVID-19 and Immunological Dysregulation: Can Autoantibodies be Useful?
Pascolini, Simona; Vannini, Antonio; Deleonardi, Gaia; Ciordinik, Michele; Sensoli, Annamaria; Carletti, Ilaria; Veronesi, Lorenza; Ricci, Chiara; Pronesti, Alessia; Mazzanti, Laura; Grondona, Ana; Silvestri, Tania; Zanuso, Stefano; Mazzolini, Marcello; Lalanne, Claudine; Quarneti, Chiara; Fusconi, Marco; Giostra, Fabrizio; Granito, Alessandro; Muratori, Luigi; Lenzi, Marco; Muratori, Paolo.
  • Pascolini S; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Vannini A; Medicina d'Urgenza e Pronto Soccorso, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Deleonardi G; Metropolitan Laboratory, Department of Immunology, AUSL Bologna, Bologna, Italy.
  • Ciordinik M; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Sensoli A; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Carletti I; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Veronesi L; Medicina d'Urgenza e Pronto Soccorso, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Ricci C; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Pronesti A; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Mazzanti L; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Grondona A; Metropolitan Laboratory, Department of Immunology, AUSL Bologna, Bologna, Italy.
  • Silvestri T; Metropolitan Laboratory, Department of Immunology, AUSL Bologna, Bologna, Italy.
  • Zanuso S; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Mazzolini M; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Lalanne C; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Quarneti C; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Fusconi M; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Giostra F; Medicina d'Urgenza e Pronto Soccorso, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Granito A; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Muratori L; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
  • Lenzi M; Division of Internal Medicine, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
  • Muratori P; Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy.
Clin Transl Sci ; 14(2): 502-508, 2021 03.
Article in English | MEDLINE | ID: covidwho-802539
ABSTRACT
Coronavirus disease 2019 (COVID-19) is often associated with interstitial pneumonia. However, there is insufficient knowledge on the presence of autoimmune serological markers in patients with COVID-19. We analyzed the presence and role of autoantibodies in patients with COVID-19-associated pneumonia. We prospectively studied 33 consecutive patients with COVID-19, 31 (94%) of whom had interstitial pneumonia, and 25 age-matched and sex-matched patients with fever and/or pneumonia with etiologies other than COVID-19 as the pathological control group. All patients were tested for the presence of antinuclear antibodies (ANAs), anti-antiphospholipid antibodies, and anti-cytoplasmic neutrophil antibodies (ANCAs). Clinical, biochemical, and radiological parameters were also collected. Fifteen of 33 patients (45%) tested positive for at least one autoantibody, including 11 who tested positive for ANAs (33%), 8 who tested positive for anti-cardiolipin antibodies (immunoglobulin (Ig)G and/or IgM; 24%), and 3 who tested positive for anti-ß2-glycoprotein antibodies (IgG and/or IgM; 9%). ANCA reactivity was not detected in any patient. Patients that tested positive for auto-antibodies had a significantly more severe prognosis than other patients did 6 of 15 patients (40%) with auto-antibodies died due to COVID-19 complications during hospitalization, whereas only 1 of 18 patients (5.5%) who did not have auto-antibodies died (P = 0.03). Patients with poor prognosis (death due to COVID-19 complications) had a significantly higher respiratory rate at admission (23 breaths per minute vs. 17 breaths per minute; P = 0.03) and a higher frequency of auto-antibodies (86% vs. 27%; P = 0.008). In conclusion, auto-antibodies are frequently detected in patients with COVID-19 possibly reflecting a pathogenetic role of immune dysregulation. However, given the small number of patients, the association of auto-antibodies with an unfavorable prognosis requires further multicenter studies.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / SARS-CoV-2 / COVID-19 / Immune System Diseases Type of study: Etiology study / Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Transl Sci Year: 2021 Document Type: Article Affiliation country: Cts.12908

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Autoantibodies / SARS-CoV-2 / COVID-19 / Immune System Diseases Type of study: Etiology study / Experimental Studies / Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Clin Transl Sci Year: 2021 Document Type: Article Affiliation country: Cts.12908