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Management of COVID-19 Coagulopathy in a Patient with Severe Haemophilia A.
Pinto Pereira, João; Hantson, Philippe; Gerard, Ludovic; Wittebole, Xavier; Laterre, Pierre-François; Lambert, Catherine; Hermans, Cédric.
  • Pinto Pereira J; Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Hantson P; Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium, philippe.hantson@uclouvain.be.
  • Gerard L; Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Wittebole X; Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Laterre PF; Department of Intensive Care, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Lambert C; Department of Haematology, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
  • Hermans C; Department of Haematology, Cliniques St-Luc, Université Catholique de Louvain, Brussels, Belgium.
Acta Haematol ; 144(3): 319-321, 2021.
Article in English | MEDLINE | ID: covidwho-802601
ABSTRACT
A 54-year-old man with a long history of severe haemophilia A treated prophylactically with efmoroctocog alpha (3,000 IU twice weekly) was diagnosed with COVID-19 infection. He had multiple risk factors for COVID-19 severity including obesity, diabetes mellitus and hypertension. He required prolonged intensive care unit (ICU) stay due to the severity of respiratory failure until his death on day 24. During his ICU stay, he received a continuous infusion of efmoroctocog alpha in order to maintain factor VIII activity between 80 and 100%, together with therapeutic doses of low-molecular-weight heparin targeting anti-Xa activity above 0.5 IU/mol. He tolerated numerous invasive procedures without bleeding. At post-mortem examination, there was no evidence for thrombosis or haemorrhage in the different organs.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Recombinant Fusion Proteins / Factor VIII / Immunoglobulin Fc Fragments / Heparin, Low-Molecular-Weight / COVID-19 / Hemophilia A Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Acta Haematol Year: 2021 Document Type: Article Affiliation country: 000510591

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Recombinant Fusion Proteins / Factor VIII / Immunoglobulin Fc Fragments / Heparin, Low-Molecular-Weight / COVID-19 / Hemophilia A Type of study: Case report / Diagnostic study / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Acta Haematol Year: 2021 Document Type: Article Affiliation country: 000510591