A Review on the Neurological Manifestations of COVID-19 Infection: a Mechanistic View.
Mol Neurobiol
; 58(2): 536-549, 2021 Feb.
Article
in English
| MEDLINE | ID: covidwho-802975
ABSTRACT
There is increasing evidence of neurological manifestations and complications in patients with coronavirus disease 19 (COVID-19). More than one-quarter of patients with COVID-19 developed various neurological symptoms, ranging from headache and dizziness to more serious medical conditions, such as seizures and stroke. The recent investigations introduced hyposmia as a potential early criterion of infection with COVID-19. Despite the high mortality and morbidity rate of COVID-19, its exact mechanism of action and pathogenesis is not well characterized. The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) could interact with angiotensin-converting enzyme 2 (ACE2) in the endothelial, neural, and glial cells. In the present study, we reviewed the most common neurological manifestations and complications that emerged after infection with the SARS-CoV-2 and discussed their possible relation to the expression and function of ACE2. Comprehensive and detailed studies are required to uncover how this virus invades the neural system as well as other critical organs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Seizures
/
Stroke
/
Dizziness
/
COVID-19
/
Headache
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Mol Neurobiol
Journal subject:
Molecular Biology
/
Neurology
Year:
2021
Document Type:
Article
Affiliation country:
S12035-020-02149-0
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