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COVID-19-Related Anosmia: The Olfactory Pathway Hypothesis and Early Intervention.
Gori, Alessandra; Leone, Fabrizio; Loffredo, Lorenzo; Cinicola, Bianca Laura; Brindisi, Giulia; De Castro, Giovanna; Spalice, Alberto; Duse, Marzia; Zicari, Anna Maria.
  • Gori A; Department of Pediatrics, Sapienza University, Rome, Italy.
  • Leone F; Department of Pediatrics, Sapienza University, Rome, Italy.
  • Loffredo L; Department of Internal Medicine and Medical Specialties, Sapienza University, Rome, Italy.
  • Cinicola BL; Department of Pediatrics, Sapienza University, Rome, Italy.
  • Brindisi G; Department of Pediatrics, Sapienza University, Rome, Italy.
  • De Castro G; Department of Pediatrics, Sapienza University, Rome, Italy.
  • Spalice A; Child Neurology Division, Department of Pediatrics, Sapienza University of Rome, Rome, Italy.
  • Duse M; Department of Pediatrics, Sapienza University, Rome, Italy.
  • Zicari AM; Department of Pediatrics, Sapienza University, Rome, Italy.
Front Neurol ; 11: 956, 2020.
Article in English | MEDLINE | ID: covidwho-804851
ABSTRACT
Anosmia is a well-described symptom of Corona Virus Disease 2019 (COVID-19). Several respiratory viruses are able to cause post-viral olfactory dysfunction, suggesting a sensorineural damage. Since the olfactory bulb is considered an immunological organ contributing to prevent the invasion of viruses, it could have a role in host defense. The inflammatory products locally released in COVID-19, leading to a local damage and causing olfactory loss, simultaneously may interfere with the viral spread into the central nervous system. In this context, olfactory receptors could play a role as an alternative way of SARS-CoV-2 entry into cells locally, in the central nervous system, and systemically. Differences in olfactory bulb due to sex and age may contribute to clarify the different susceptibility to infection and understand the role of age in transmission and disease severity. Finally, evaluation of the degree of functional impairment (grading), central/peripheral anosmia (localization), and the temporal course (evolution) may be useful tools to counteract COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Front Neurol Year: 2020 Document Type: Article Affiliation country: Fneur.2020.00956

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Front Neurol Year: 2020 Document Type: Article Affiliation country: Fneur.2020.00956