Teachings from COVID-19 and aging-An oxidative process.
J Cosmet Dermatol
; 19(12): 3171-3176, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-806600
ABSTRACT
As of June 2020, the COVID-19 pandemic has totaled over 9 000 000 cases and 470 000 deaths globally (ref. 1). Emerging data from COVID-19 patients have suggested a clear role for oxidative stress in the pathogenesis of SARS-CoV-2, the pathogenic agent of COVID-19. Several comorbidities, including hypertension, diabetes, obesity, and aging, have been associated with an increase in baseline oxidative stress, likely explaining why such individuals at risk for poor outcomes with SARS-CoV-2 infection. Similarly, the concept of oxidative stress remains one of the best supported theories to explain the mechanism behind aging. Oxidative stress through both endogenous and exogenous sources has known deleterious effects in both aging and SARS-CoV-2 infection. Herein, we will review the role of oxidative stress as a key player in both aging and COVID-19 and highlight why some individuals may have better or poorer outcomes because of this. Additionally, we will discuss potential therapeutic pathways for effectively anti-aging as we take away from our learnings on COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Aging
/
Oxidative Stress
/
COVID-19
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
J Cosmet Dermatol
Journal subject:
Dermatology
Year:
2020
Document Type:
Article
Affiliation country:
Jocd.13751
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