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Deep Immune Profiling of MIS-C demonstrates marked but transient immune activation compared to adult and pediatric COVID-19.
medRxiv ; 2020 Oct 06.
Article in English | MEDLINE | ID: covidwho-807631
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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Semantic information from SemMedBD (by NLM)
1. Severe Acute Respiratory Syndrome PRECEDES COVID-19
Subject
Severe Acute Respiratory Syndrome
Predicate
PRECEDES
Object
COVID-19
2. Mild disorder PROCESS_OF Adult
Subject
Mild disorder
Predicate
PROCESS_OF
Object
Adult
3. Present COEXISTS_WITH Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Subject
Present
Predicate
COEXISTS_WITH
Object
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
4. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Patients
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Patients
5. Immune response PROCESS_OF hospitalized patients
Subject
Immune response
Predicate
PROCESS_OF
Object
hospitalized patients
6. Malaise PROCESS_OF Adult
Subject
Malaise
Predicate
PROCESS_OF
Object
Adult
7. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Adult
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Adult
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
9. Respiratory Distress Syndrom PROCESS_OF C0030705
Subject
Respiratory Distress Syndrom
Predicate
PROCESS_OF
Object
C0030705
10. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects COEXISTS_WITH Illness (finding)
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
COEXISTS_WITH
Object
Illness (finding)
11. Severe Acute Respiratory Syndrome PRECEDES COVID-19
Subject
Severe Acute Respiratory Syndrome
Predicate
PRECEDES
Object
COVID-19
12. Mild disorder PROCESS_OF Adult
Subject
Mild disorder
Predicate
PROCESS_OF
Object
Adult
13. Present COEXISTS_WITH Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Subject
Present
Predicate
COEXISTS_WITH
Object
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
14. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Patients
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Patients
15. Immune response PROCESS_OF hospitalized patients
Subject
Immune response
Predicate
PROCESS_OF
Object
hospitalized patients
16. Malaise PROCESS_OF Adult
Subject
Malaise
Predicate
PROCESS_OF
Object
Adult
17. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects PROCESS_OF Adult
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
PROCESS_OF
Object
Adult
18. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
19. Respiratory Distress Syndrome, Adult PROCESS_OF Patients
Subject
Respiratory Distress Syndrome, Adult
Predicate
PROCESS_OF
Object
Patients
20. Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects COEXISTS_WITH Illness (finding)
Subject
Congenital Hemidysplasia with Ichthyosiform Erythroderma and Limb Defects
Predicate
COEXISTS_WITH
Object
Illness (finding)
ABSTRACT
Pediatric COVID-19 following SARS-CoV-2 infection is associated with fewer hospitalizations and often milder disease than in adults. A subset of children, however, present with Multisystem Inflammatory Syndrome in Children (MIS-C) that can lead to vascular complications and shock, but rarely death. The immune features of MIS-C compared to pediatric COVID-19 or adult disease remain poorly understood. We analyzed peripheral blood immune responses in hospitalized SARS-CoV-2 infected pediatric patients (pediatric COVID-19) and patients with MIS-C. MIS-C patients had patterns of T cell-biased lymphopenia and T cell activation similar to severely ill adults, and all patients with MIS-C had SARS-CoV-2 spike-specific antibodies at admission. A distinct feature of MIS-C patients was robust activation of vascular patrolling CX3CR1+ CD8 T cells that correlated with use of vasoactive medication. Finally, whereas pediatric COVID-19 patients with acute respiratory distress syndrome (ARDS) had sustained immune activation, MIS-C patients displayed clinical improvement over time, concomitant with decreasing immune activation. Thus, non-MIS-C versus MIS-C SARS-CoV-2 associated illnesses are characterized by divergent immune signatures that are temporally distinct and implicate CD8 T cells in clinical presentation and trajectory of MIS-C.

Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Language: English Year: 2020 Document Type: Article