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Genomic and phylogenetic characterisation of an imported case of SARS-CoV-2 in Amazonas State, Brazil.
Nascimento, Valdinete Alves do; Corado, André de Lima Guerra; Nascimento, Fernanda Oliveira do; Costa, Ágatha Kelly Araújo da; Duarte, Debora Camila Gomes; Luz, Sérgio Luiz Bessa; Gonçalves, Luciana Mara Fé; Jesus, Michele Silva de; Costa, Cristiano Fernandes da; Delatorre, Edson; Naveca, Felipe Gomes.
  • Nascimento VAD; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.
  • Corado ALG; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Programa de Pós-Graduação em Biologia Celular e Molecular, Rio de Janeiro, RJ, Brasil.
  • Nascimento FOD; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.
  • Costa ÁKAD; Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Programa de Pós-Graduação em Biologia Celular e Molecular, Rio de Janeiro, RJ, Brasil.
  • Duarte DCG; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.
  • Luz SLB; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Programa de Pós-Graduação em Biologia da Interação Patógeno-Hospedeiro, Manaus, AM, Brasil.
  • Gonçalves LMF; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.
  • Jesus MS; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Programa de Pós-Graduação em Biologia da Interação Patógeno-Hospedeiro, Manaus, AM, Brasil.
  • Costa CFD; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.
  • Delatorre E; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Manaus, AM, Brasil.
  • Naveca FG; Fundação Oswaldo Cruz-Fiocruz, Instituto Leônidas e Maria Deane, Programa de Pós-Graduação em Biologia da Interação Patógeno-Hospedeiro, Manaus, AM, Brasil.
Mem Inst Oswaldo Cruz ; 115: e200310, 2020.
Article in English | MEDLINE | ID: covidwho-807975
ABSTRACT
A new coronavirus [severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] is currently causing a life-threatening pandemic. In this study, we report the complete genome sequencing and genetic characterisation of a SARS-CoV-2 detected in Manaus, Amazonas, Brazil, and the protocol we designed to generate high-quality SARS-CoV-2 full genome data. The isolate was obtained from an asymptomatic carrier returning from Madrid, Spain. Nucleotide sequence analysis showed a total of nine mutations in comparison with the original human case in Wuhan, China, and support this case as belonging to the recently proposed lineage A.2. Phylogeographic analysis further confirmed the likely European origin of this case. To our knowledge, this is the first SARS-CoV-2 genome obtained from the North Brazilian Region. We believe that the information generated in this study may contribute to the ongoing efforts toward the SARS-CoV-2 emergence.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phylogeny / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Randomized controlled trials Limits: Humans Country/Region as subject: South America / Brazil / Europa Language: English Journal: Mem Inst Oswaldo Cruz Year: 2020 Document Type: Article Affiliation country: 0074-02760200310

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Phylogeny / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Randomized controlled trials Limits: Humans Country/Region as subject: South America / Brazil / Europa Language: English Journal: Mem Inst Oswaldo Cruz Year: 2020 Document Type: Article Affiliation country: 0074-02760200310