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New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19.
El Tabaa, Manar Mohammed; El Tabaa, Maram Mohammed.
  • El Tabaa MM; Pharmacology & Environmental Toxicology, Environmental Studies & Research Institute, University of Sadat City, Egypt. Electronic address: manar.eltabaa@esri.usc.edu.eg.
  • El Tabaa MM; Medical Physiology, Faculty of Medicine, Tanta University, Egypt. Electronic address: maram.eltabaa@med.tanta.edu.eg.
Eur J Pharmacol ; 889: 173615, 2020 Dec 15.
Article in English | MEDLINE | ID: covidwho-808499
ABSTRACT
Nowadays, coronavirus disease 2019 (COVID-19) represents the most serious inflammatory respiratory disease worldwide. Despite many proposed therapies, no effective medication has yet been approved. Neutrophils appear to be the key mediator for COVID-19-associated inflammatory immunopathologic, thromboembolic and fibrotic complications. Thus, for any therapeutic agent to be effective, it should greatly block the neutrophilic component of COVID-19. One of the effective therapeutic approaches investigated to reduce neutrophil-associated inflammatory lung diseases with few adverse effects was roflumilast. Being a highly selective phosphodiesterase-4 inhibitors (PDE4i), roflumilast acts by enhancing the level of cyclic adenosine monophosphate (cAMP), that probably potentiates its anti-inflammatory action via increasing neprilysin (NEP) activity. Because activating NEP was previously reported to mitigate several airway inflammatory ailments; this review thoroughly discusses the proposed NEP-based therapeutic properties of roflumilast, which may be of great importance in curing COVID-19. However, further clinical studies are required to confirm this strategy and to evaluate its in vivo preventive and therapeutic efficacy against COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Benzamides / Neprilysin / COVID-19 Drug Treatment / Aminopyridines Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Benzamides / Neprilysin / COVID-19 Drug Treatment / Aminopyridines Type of study: Experimental Studies / Prognostic study Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article