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JIB-04 has broad-spectrum antiviral activity and inhibits SARS-CoV-2 replication and coronavirus pathogenesis.
Son, Juhee; Huang, Shimeng; Zeng, Qiru; Bricker, Traci L; Case, James Brett; Zhou, Jinzhu; Zang, Ruochen; Liu, Zhuoming; Chang, Xinjian; Harastani, Houda H; Chen, Lu; Castro, Maria Florencia Gomez; Zhao, Yongxiang; Kohio, Hinissan P; Hou, Gaopeng; Fan, Baochao; Niu, Beibei; Guo, Rongli; Rothlauf, Paul W; Bailey, Adam L; Wang, Xin; Shi, Pei-Yong; Martinez, Elisabeth D; Whelan, Sean P J; Diamond, Michael S; Boon, Adrianus C M; Li, Bin; Ding, Siyuan.
  • Son J; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Huang S; Program in Molecular Cell Biology, Washington University School of Medicine, St. Louis, MO, USA.
  • Zeng Q; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Bricker TL; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Case JB; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
  • Zhou J; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
  • Zang R; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Liu Z; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Chang X; Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, China.
  • Harastani HH; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Chen L; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Castro MFG; Department of Medicine, Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO, USA.
  • Zhao Y; National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD, USA.
  • Kohio HP; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Hou G; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Fan B; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Niu B; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Guo R; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Rothlauf PW; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Bailey AL; Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, China.
  • Wang X; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Shi PY; Program in Virology, Harvard Medical School, Boston, MA, USA.
  • Martinez ED; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
  • Whelan SPJ; Key Laboratory of Marine Drugs, Ministry of Education, Ocean University of China, Qingdao, China.
  • Diamond MS; Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston TX, USA.
  • Boon ACM; Department of Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.
  • Li B; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
  • Ding S; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO, USA.
bioRxiv ; 2021 Jun 04.
Article in English | MEDLINE | ID: covidwho-808504
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
Pathogenic coronaviruses represent a major threat to global public health. Here, using a recombinant reporter virus-based compound screening approach, we identified several small-molecule inhibitors that potently block the replication of the newly emerged severe acute respiratory syndrome virus 2 (SARS-CoV-2). Among them, JIB-04 inhibited SARS-CoV-2 replication in Vero E6 cells with an EC50 of 695 nM, with a specificity index of greater than 1,000. JIB-04 showed in vitro antiviral activity in multiple cell types against several DNA and RNA viruses, including porcine coronavirus transmissible gastroenteritis virus. In an in vivo porcine model of coronavirus infection, administration of JIB-04 reduced virus infection and associated tissue pathology, which resulted in improved weight gain and survival. These results highlight the potential utility of JIB-04 as an antiviral agent against SARS-CoV-2 and other viral pathogens.

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: 2020.09.24.312165

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Year: 2021 Document Type: Article Affiliation country: 2020.09.24.312165