Porcine epidemic diarrhea virus: Molecular mechanisms of attenuation and vaccines.
Microb Pathog
; 149: 104553, 2020 Dec.
Article
in English
| MEDLINE | ID: covidwho-808667
ABSTRACT
Porcine epidemic diarrhea virus (PEDV) causes an emerging and re-emerging coronavirus disease characterized by vomiting, acute diarrhea, dehydration, and up to 100% mortality in neonatal suckling piglets, leading to huge economic losses in the global swine industry. Vaccination remains the most promising and effective way to prevent and control PEDV. However, effective vaccines for PEDV are still under development. Understanding the genomic structure and function of PEDV and the influence of the viral components on innate immunity is essential for developing effective vaccines. In the current review, we systematically describe the recent developments in vaccine against PEDV and the roles of structural proteins, non-structural proteins and accessory proteins of PEDV in affecting viral virulence and regulating innate immunity, which will provide insight into the rational design of effective and safe vaccines for PEDV or other coronaviruses.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Swine Diseases
/
Viral Vaccines
/
Coronavirus Infections
/
Porcine epidemic diarrhea virus
Topics:
Vaccines
Limits:
Animals
Language:
English
Journal:
Microb Pathog
Journal subject:
Communicable Diseases
/
Microbiology
Year:
2020
Document Type:
Article
Affiliation country:
J.micpath.2020.104553
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