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Susceptibility of tree shrew to SARS-CoV-2 infection.
Zhao, Yuan; Wang, Junbin; Kuang, Dexuan; Xu, Jingwen; Yang, Mengli; Ma, Chunxia; Zhao, Siwen; Li, Jingmei; Long, Haiting; Ding, Kaiyun; Gao, Jiahong; Liu, Jiansheng; Wang, Haixuan; Li, Haiyan; Yang, Yun; Yu, Wenhai; Yang, Jing; Zheng, Yinqiu; Wu, Daoju; Lu, Shuaiyao; Liu, Hongqi; Peng, Xiaozhong.
  • Zhao Y; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Wang J; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Kuang D; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Xu J; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Yang M; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Ma C; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Zhao S; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Li J; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Long H; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Ding K; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Gao J; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Liu J; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Wang H; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Li H; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Yang Y; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Yu W; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Yang J; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Zheng Y; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Wu D; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China.
  • Lu S; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China. lushuaiyao-km@163.com.
  • Liu H; State Key Laboratory of Medical Molecular Biology, Department of Molecular Biology and Biochemistry, Institute of Basic Medical Sciences, Medical Primate Research Center, Neuroscience Center, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.
  • Peng X; National Kunming High-Level Biosafety Primate Research Center, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Yunnan, China. lhq@Imbcams.com.cn.
Sci Rep ; 10(1): 16007, 2020 09 29.
Article in English | MEDLINE | ID: covidwho-809120
Preprint
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Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus PROCESS_OF World
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
World
2. Severe Acute Respiratory Syndrome AFFECTS Animal
Subject
Severe Acute Respiratory Syndrome
Predicate
AFFECTS
Object
Animal
3. Viral Shedding OCCURS_IN Human Age Group
Subject
Viral Shedding
Predicate
OCCURS_IN
Object
Human Age Group
4. 2019 novel coronavirus PROCESS_OF World
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
World
5. Severe Acute Respiratory Syndrome AFFECTS Animals, Wild
Subject
Severe Acute Respiratory Syndrome
Predicate
AFFECTS
Object
Animals, Wild
6. Viral Shedding OCCURS_IN Human Age Group
Subject
Viral Shedding
Predicate
OCCURS_IN
Object
Human Age Group
ABSTRACT
Since severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) became a pandemic event in the world, it has not only caused huge economic losses, but also a serious threat to global public health. Many scientific questions about SARS-CoV-2 and Coronavirus disease (COVID-19) were raised and urgently need to be answered, including the susceptibility of animals to SARS-CoV-2 infection. Here we tested whether tree shrew, an emerging experimental animal domesticated from wild animal, is susceptible to SARS-CoV-2 infection. No clinical signs were observed in SARS-CoV-2 inoculated tree shrews during this experiment except the increasing body temperature particularly in female animals. Low levels of virus shedding and replication in tissues occurred in all three age groups. Notably, young tree shrews (6 months to 12 months) showed virus shedding at the earlier stage of infection than adult (2 years to 4 years) and old (5 years to 7 years) animals that had longer duration of virus shedding comparatively. Histopathological examine revealed that pulmonary abnormalities were the main changes but mild although slight lesions were also observed in other tissues. In summary, tree shrew is less susceptible to SARS-CoV-2 infection compared with the reported animal models and may not be a suitable animal for COVID-19 related researches. However, tree shrew may be a potential intermediate host of SARS-CoV-2 as an asymptomatic carrier.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Tupaiidae / Coronavirus Infections / Host Specificity / Pandemics Type of study: Randomized controlled trials Limits: Animals Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-72563-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Tupaiidae / Coronavirus Infections / Host Specificity / Pandemics Type of study: Randomized controlled trials Limits: Animals Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-72563-w