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Ultrastructural analysis of SARS-CoV-2 interactions with the host cell via high resolution scanning electron microscopy.
Caldas, Lucio Ayres; Carneiro, Fabiana Avila; Higa, Luiza Mendonça; Monteiro, Fábio Luiz; da Silva, Gustavo Peixoto; da Costa, Luciana Jesus; Durigon, Edison Luiz; Tanuri, Amilcar; de Souza, Wanderley.
  • Caldas LA; Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Cidade Universitária. Av., Carlos Chagas Filho 373, Prédio CCS, Bloco C, subsolo, CEP: 21941902, Rio de Janeiro, RJ, Brazil. lucio@biof.ufrj.br.
  • Carneiro FA; Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem, Rio de Janeiro, Brazil. lucio@biof.ufrj.br.
  • Higa LM; Núcleo Multidisciplinar de Pesquisa UFRJ-Xerém em Biologia - NUMPEX-BIO, Universidade Federal Do Rio de Janeiro, Campus Duque de Caxias Geraldo Cidade. CEP: 25265-970, Rio de Janeiro, RJ, Brazil. lucio@biof.ufrj.br.
  • Monteiro FL; Núcleo Multidisciplinar de Pesquisa UFRJ-Xerém em Biologia - NUMPEX-BIO, Universidade Federal Do Rio de Janeiro, Campus Duque de Caxias Geraldo Cidade. CEP: 25265-970, Rio de Janeiro, RJ, Brazil.
  • da Silva GP; Departamento de Genética, Instituto de Biologia, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.
  • da Costa LJ; Departamento de Genética, Instituto de Biologia, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Durigon EL; Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.
  • Tanuri A; Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, Brazil.
  • de Souza W; Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Sci Rep ; 10(1): 16099, 2020 09 30.
Article in English | MEDLINE | ID: covidwho-809222
Preprint
This scientific journal article is probably based on a previously available preprint. It has been identified through a machine matching algorithm, human confirmation is still pending.
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ABSTRACT
SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Here, we investigated the interaction of this new coronavirus with Vero cells using high resolution scanning electron microscopy. Surface morphology, the interior of infected cells and the distribution of viral particles in both environments were observed 2 and 48 h after infection. We showed areas of viral processing, details of vacuole contents, and viral interactions with the cell surface. Intercellular connections were also approached, and viral particles were adhered to these extensions suggesting direct cell-to-cell transmission of SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Host-Pathogen Interactions / Betacoronavirus Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-73162-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Host-Pathogen Interactions / Betacoronavirus Limits: Animals / Humans Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-73162-5