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Rationale for ozone-therapy as an adjuvant therapy in COVID-19: a narrative review.
Ranaldi, Giovanni Tommaso; Villani, Emanuele Rocco; Franza, Laura.
  • Ranaldi GT; Unità Operativa Semplice Dipartimentale Farmacologia Clinica e Sperimentazione Clinica, Azienda Sanitaria, Potenza, Italy.
  • Villani ER; Department of Geriatrics, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Franza L; Department of Emergency Medicine, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy.
Med Gas Res ; 10(3): 134-138, 2020.
Article in English | MEDLINE | ID: covidwho-809850
ABSTRACT
Coronavirus disease 2019 (COVID-19) is the respiratory disease caused by the novel severe acute respiratory syndrome-coronavirus-2 and is characterized by clinical manifestations ranging from mild, flu-like symptoms to severe respiratory insufficiency and multi-organ failure. Patients with more severe symptoms may require intensive care treatments and face a high mortality risk. Also, thrombotic complications such as pulmonary embolisms and disseminated intravascular coagulation are frequent in these patients. Indeed, COVID-19 is characterized by an abnormal inflammatory response resembling a cytokine storm, which is associated to endothelial dysfunction and microvascular complications. To date, no specific treatments are available for COVID-19 and its life-threatening complication. Immunomodulatory drugs, such as hydroxychloroquine and interleukin-6 inhibitors, as well as antithrombotic drugs such as heparin and low molecular weight heparin, are currently being administered with some benefit. Ozone therapy consists in the administration of a mixture of ozone and oxygen, called medical ozone, which has been used for over a century as an unconventional medicine practice for several diseases. Medical ozone rationale in COVID-19 is the possibility of contrasting endothelial dysfunction, modulating the immune response and acting as a virustatic agent. Thus, medical ozone could help to decrease lung inflammation, slow down viral growth, regulate lung circulation and oxygenation and prevent microvascular thrombosis. Ozone-therapy could be considered a feasible, cost-effective and easy to administer adjuvant therapy while waiting for the synthesis of a therapy or the development of the vaccine.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ozone / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Med Gas Res Year: 2020 Document Type: Article Affiliation country: 2045-9912.289462

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Ozone / Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Med Gas Res Year: 2020 Document Type: Article Affiliation country: 2045-9912.289462