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Potential Therapeutic Benefits of Dipyridamole in COVID-19 Patients.
Aliter, Kholoud F; Al-Horani, Rami A.
  • Aliter KF; Department of Chemistry, School of STEM, Dillard University, New Orleans, LA 70122, United States.
  • Al-Horani RA; Division of Basic Pharmaceutical Sciences, College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125, United States.
Curr Pharm Des ; 27(6): 866-875, 2021.
Article in English | MEDLINE | ID: covidwho-810094
Semantic information from SemMedBD (by NLM)
1. dipyridamole TREATS COVID-19
Subject
dipyridamole
Predicate
TREATS
Object
COVID-19
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. dipyridamole TREATS Patients
Subject
dipyridamole
Predicate
TREATS
Object
Patients
4. Coronavirus Infections CAUSES COVID-19
Subject
Coronavirus Infections
Predicate
CAUSES
Object
COVID-19
5. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
6. Vaccines NEG_PART_OF Eye
Subject
Vaccines
Predicate
NEG_PART_OF
Object
Eye
7. Eye PART_OF Persons
Subject
Eye
Predicate
PART_OF
Object
Persons
8. Thrombophilia COEXISTS_WITH Respiratory Tract Infections
Subject
Thrombophilia
Predicate
COEXISTS_WITH
Object
Respiratory Tract Infections
9. Adjuvant Therapy TREATS COVID-19
Subject
Adjuvant Therapy
Predicate
TREATS
Object
COVID-19
10. Antiplatelet Agents PREVENTS Cerebrovascular accident
Subject
Antiplatelet Agents
Predicate
PREVENTS
Object
Cerebrovascular accident
11. dipyridamole TREATS COVID-19
Subject
dipyridamole
Predicate
TREATS
Object
COVID-19
12. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
13. dipyridamole TREATS Patients
Subject
dipyridamole
Predicate
TREATS
Object
Patients
14. Coronavirus Infections CAUSES COVID-19
Subject
Coronavirus Infections
Predicate
CAUSES
Object
COVID-19
15. Infected PROCESS_OF Persons
Subject
Infected
Predicate
PROCESS_OF
Object
Persons
16. Vaccines NEG_PART_OF Eye
Subject
Vaccines
Predicate
NEG_PART_OF
Object
Eye
17. Eye PART_OF Persons
Subject
Eye
Predicate
PART_OF
Object
Persons
18. Thrombophilia COEXISTS_WITH Respiratory Tract Infections
Subject
Thrombophilia
Predicate
COEXISTS_WITH
Object
Respiratory Tract Infections
19. Adjuvant Therapy TREATS COVID-19
Subject
Adjuvant Therapy
Predicate
TREATS
Object
COVID-19
20. Antiplatelet Agents PREVENTS Cerebrovascular accident
Subject
Antiplatelet Agents
Predicate
PREVENTS
Object
Cerebrovascular accident
ABSTRACT

BACKGROUND:

COVID-19 pandemic is caused by coronavirus also known as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The viral infection continues to impact the globe with no vaccine to prevent the infection or highly effective therapeutics to treat the millions of infected people around the world. The disease starts as a respiratory infection, yet it may also be associated with a hypercoagulable state, severe inflammation owing to excessive cytokines production, and a potentially significant oxidative stress. The disease may progress to multiorgan failure and eventually death.

OBJECTIVE:

In this article, we summarize the potential of dipyridamole as an adjunct therapy for COVID-19.

METHODS:

We reviewed the literature describing the biological activities of dipyridamole in various settings of testing. Data were retrieved from PubMed, SciFinder-CAS, and Web of Science. The review concisely covered relevant studies starting from 1977.

RESULTS:

Dipyridamole is an approved antiplatelet drug, that has been used to prevent stroke, among other indications. Besides its antithrombotic activity, the literature indicates that dipyridamole also promotes a host of other biological activities including antiviral, anti-inflammatory, and antioxidant ones.

CONCLUSION:

Dipyridamole may substantially help improve the clinical outcomes of COVID-19 treatment. The pharmacokinetics profile of the drug is well established which makes it easier to design an appropriate therapeutic course. The drug is also generally safe, affordable, and available worldwide. Initial clinical trials have shown a substantial promise for dipyridamole in treating critically ill COVID-19 patients, yet larger randomized and controlled trials are needed to confirm this promise.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Curr Pharm Des Journal subject: Pharmacy Year: 2021 Document Type: Article Affiliation country: 1381612826666201001125604

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pandemics / COVID-19 Type of study: Controlled clinical trial / Randomized controlled trials / Reviews Topics: Vaccines Limits: Humans Language: English Journal: Curr Pharm Des Journal subject: Pharmacy Year: 2021 Document Type: Article Affiliation country: 1381612826666201001125604