Light and corona: guided-wave readout for coronavirus spike protein-host-receptor binding.
Opt Lett
; 45(19): 5428-5431, 2020 Oct 01.
Article
in English
| MEDLINE | ID: covidwho-810278
ABSTRACT
We show that waveguide sensors can enable a quantitative characterization of coronavirus spike glycoprotein-host-receptor binding-the process whereby coronaviruses enter human cells, causing disease. We demonstrate that such sensors can help quantify and eventually understand kinetic and thermodynamic properties of viruses that control their affinity to targeted cells, which is known to significantly vary in the course of virus evolution, e.g., from SARS-CoV to SARS-CoV-2, making the development of virus-specific drugs and vaccine difficult. With the binding rate constants and thermodynamic parameters as suggested by the latest SARS-CoV-2 research, optical sensors of SARS-CoV-2 spike protein-receptor binding may be within sight.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Receptors, Virus
/
Biosensing Techniques
/
Coronavirus Infections
/
Peptidyl-Dipeptidase A
/
Optics and Photonics
/
Pandemics
/
Spike Glycoprotein, Coronavirus
/
Betacoronavirus
Type of study:
Prognostic study
Topics:
Vaccines
Limits:
Humans
Language:
English
Journal:
Opt Lett
Year:
2020
Document Type:
Article
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