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A Novel Use of Romiplostim for SARS-CoV-2-induced Thrombocytopenia.
Schneider, Coursen W; Penney, Scott W; Helfrich, Alison M; Hartman, Kip R; Lieuw, Kenneth.
  • Schneider CW; Departments of Pediatrics.
  • Penney SW; Pediatric Hematology/Oncology.
  • Helfrich AM; Pediatric Infectious Disease, Walter Reed National Military Medical Center, Bethesda, MD.
  • Hartman KR; Pediatric Hematology/Oncology.
  • Lieuw K; Pediatric Hematology/Oncology.
J Pediatr Hematol Oncol ; 43(6): e788-e790, 2021 08 01.
Article in English | MEDLINE | ID: covidwho-811165
ABSTRACT
The literature regarding coronavirus disease of 2019 (COVID-19) infection in pediatrics indicates that children have less severe clinical presentations and lower mortality rates. There remains limited data regarding hematologic sequelae in pediatric patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Romiplostim has shown a platelet response in pediatric patients with chronic immune thrombocytopenic purpura, and eltrombopag is proven to increase platelet counts in patients with inherited thrombocytopenia. We review SARS-CoV-2-associated thrombocytopenia and present a pediatric patient with acute on chronic thrombocytopenia in the setting of COVID-19 with subsequent platelet recovery using romiplostim.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Thrombopoietin / Recombinant Fusion Proteins / Receptors, Fc / SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Child / Humans / Male Language: English Journal: J Pediatr Hematol Oncol Journal subject: Hematology / Neoplasms / Pediatrics Year: 2021 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Thrombocytopenia / Thrombopoietin / Recombinant Fusion Proteins / Receptors, Fc / SARS-CoV-2 / COVID-19 Type of study: Case report / Prognostic study Topics: Long Covid Limits: Child / Humans / Male Language: English Journal: J Pediatr Hematol Oncol Journal subject: Hematology / Neoplasms / Pediatrics Year: 2021 Document Type: Article