Genetics and genomics of SARS-CoV-2: A review of the literature with the special focus on genetic diversity and SARS-CoV-2 genome detection.
Genomics
; 113(1 Pt 2): 1221-1232, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-811745
ABSTRACT
The outbreak of 2019-novel coronavirus disease (COVID-19), caused by SARS-CoV-2, started in late 2019; in a short time, it has spread rapidly all over the world. Although some possible antiviral and anti-inflammatory medications are available, thousands of people are dying daily. Well-understanding of the SARS-CoV-2 genome is not only essential for the development of new treatments/vaccines, but it also can be used for improving the sensitivity and specificity of current approaches for virus detection. Accordingly, we reviewed the most critical findings related to the genetics of the SARS-CoV-2, with a specific focus on genetic diversity and reported mutations, molecular-based diagnosis assays, using interfering RNA technology for the treatment of patients, and genetic-related vaccination strategies. Additionally, considering the unanswered questions or uncertainties in these regards, different topics were discussed.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Genome, Viral
/
SARS-CoV-2
/
COVID-19
Type of study:
Diagnostic study
Topics:
Long Covid
/
Vaccines
Limits:
Humans
Language:
English
Journal:
Genomics
Journal subject:
Genetics
Year:
2021
Document Type:
Article
Affiliation country:
J.ygeno.2020.09.059
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