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A possible application of hinokitiol as a natural zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and viral infections.
Hoang, Ba X; Han, Bo.
  • Hoang BX; Department of Surgery, Nimni-Cordaba Tissue Engineering and Drug Discovery Laboratory, University of Southern California, Los Angeles, CA, USA. Electronic address: baxuanho@usc.edu.
  • Han B; Department of Surgery, Nimni-Cordaba Tissue Engineering and Drug Discovery Laboratory, University of Southern California, Los Angeles, CA, USA. Electronic address: bohan@usc.edu.
Med Hypotheses ; 145: 110333, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-813777
Semantic information from SemMedBD (by NLM)
1. Prophylactic treatment USES Anti-Infective Agents
Subject
Prophylactic treatment
Predicate
USES
Object
Anti-Infective Agents
2. Prophylactic treatment USES Ionophores
Subject
Prophylactic treatment
Predicate
USES
Object
Ionophores
3. Prophylactic treatment USES beta-thujaplicin
Subject
Prophylactic treatment
Predicate
USES
Object
beta-thujaplicin
4. Ionophores TREATS COVID-19
Subject
Ionophores
Predicate
TREATS
Object
COVID-19
5. Respiratory Tract Infections PROCESS_OF Patients
Subject
Respiratory Tract Infections
Predicate
PROCESS_OF
Object
Patients
6. zinc DISRUPTS Virus Replication
Subject
zinc
Predicate
DISRUPTS
Object
Virus Replication
7. Oxidative Stress PROCESS_OF Patients
Subject
Oxidative Stress
Predicate
PROCESS_OF
Object
Patients
8. COVID-19 PROCESS_OF high-risk group
Subject
COVID-19
Predicate
PROCESS_OF
Object
high-risk group
9. Respiratory Tract Infections AFFECTS Patients
Subject
Respiratory Tract Infections
Predicate
AFFECTS
Object
Patients
10. Pharmaceutical Preparations TREATS Virus Diseases
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
Virus Diseases
11. Pharmaceutical Preparations TREATS COVID-19
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
COVID-19
12. Prophylactic treatment USES Anti-Infective Agents
Subject
Prophylactic treatment
Predicate
USES
Object
Anti-Infective Agents
13. Prophylactic treatment USES Ionophores
Subject
Prophylactic treatment
Predicate
USES
Object
Ionophores
14. Prophylactic treatment USES beta-thujaplicin
Subject
Prophylactic treatment
Predicate
USES
Object
beta-thujaplicin
15. Ionophores TREATS COVID-19
Subject
Ionophores
Predicate
TREATS
Object
COVID-19
16. Respiratory Tract Infections PROCESS_OF Patients
Subject
Respiratory Tract Infections
Predicate
PROCESS_OF
Object
Patients
17. zinc DISRUPTS Virus Replication
Subject
zinc
Predicate
DISRUPTS
Object
Virus Replication
18. Oxidative Stress PROCESS_OF Patients
Subject
Oxidative Stress
Predicate
PROCESS_OF
Object
Patients
19. COVID-19 PROCESS_OF high-risk group
Subject
COVID-19
Predicate
PROCESS_OF
Object
high-risk group
20. Respiratory Tract Infections AFFECTS Patients
Subject
Respiratory Tract Infections
Predicate
AFFECTS
Object
Patients
21. Pharmaceutical Preparations TREATS Virus Diseases
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
Virus Diseases
22. Pharmaceutical Preparations TREATS COVID-19
Subject
Pharmaceutical Preparations
Predicate
TREATS
Object
COVID-19
ABSTRACT
Zinc and the combination with zinc ionophore have been reported in basic research and several clinical investigations as a potentially viable and economical preventive and therapeutic options for COVID-19 treatment. Zinc is a vital microelement that actively supports respiratory epithelium barrier integrity, innate and adaptive immune functions, and inflammatory regulations. Moreover, zinc may also prevent viral entry, suppress viral replication, and mitigate the damages due to oxidative stress and hyperinflammatory reaction in patients with respiratory infections. Hinokitiol (ß-thujaplicin) is a natural monoterpenoid and is considered as a safe zinc ionophore to help zinc transport into cells. It has been widely used in skin and oral care, and therapeutic products for its potent antiviral, antimicrobial, antifungal, anti-inflammatory, and anticancer applications. The ongoing COVID-19 pandemic and the significant morbidity and mortality exist in the high-risk group of patients associated with other respiratory infections such as influenza, respiratory syncytial virus, and dengue fever. There is an urgent need for the development of inexpensive, safe, and effective therapeutics to prevent and treat these viral infections. Considering that hydroxychloroquine (HCQ), the most studied zinc ionophore drug for COVID-19, is linked to potentially serious side effects, we propose the implementation of hinokitiol as a zinc ionophore and anti-infective agent for the prevention and treatment of COVID-19 and other viral infections.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Tropolone / Zinc / Monoterpenes / COVID-19 / Ionophores / Anti-Infective Agents Type of study: Prognostic study Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Tropolone / Zinc / Monoterpenes / COVID-19 / Ionophores / Anti-Infective Agents Type of study: Prognostic study Limits: Humans Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article