The therapeutic potential of targeting ACE2 in COVID-19.
Eur Rev Med Pharmacol Sci
; 24(18): 9744-9747, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-814894
ABSTRACT
OBJECTIVE:
ACE2 long served as the human gateway for multiple coronaviruses, including the currently pandemic SARS-CoV-2. This mini-review explores the potential of targeting ACE2 in blocking viral penetrance. MATERIALS ANDMETHODS:
PubMed search was conducted using the terms "coronaviridae", "peptidyl-dipeptidase A", "ACE2", "SARS", and "SARS-CoV-2". References of relevant articles were further screened by the author.RESULTS:
Four main methods of blocking ACE2-mediated viral penetrance were identified receptor blockage, receptor decoying, receptor shedding, and co-receptor inhibition.CONCLUSIONS:
Drugs that inhibit viral binding to ACE2 present a strong choice for the current, and if necessary, future outbreaks. Further research is needed to establish the clinical and pharmacological aspects of the identified candidate molecules.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Peptidyl-Dipeptidase A
/
Enzyme Inhibitors
/
Molecular Targeted Therapy
/
Betacoronavirus
Type of study:
Prognostic study
/
Reviews
Limits:
Humans
Language:
English
Journal:
Eur Rev Med Pharmacol Sci
Journal subject:
Pharmacology
/
Toxicology
Year:
2020
Document Type:
Article
Affiliation country:
Eurrev_202009_23067
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