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Clotting disorder in severe acute respiratory syndrome coronavirus 2.
Pujhari, Sujit; Paul, Sanjeeta; Ahluwalia, Jasmina; Rasgon, Jason L.
  • Pujhari S; Department of Pharmacology Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA.
  • Paul S; Department of Entomology, The Center for Infectious Disease Dynamics, and the Huck Institutes of The Life Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
  • Ahluwalia J; Animal Diagnostic Laboratory, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA.
  • Rasgon JL; Departments of Hematology, Postgraduate Institute of Medical Education & Research, Chandigarh, India.
Rev Med Virol ; 31(3): e2177, 2021 05.
Article in English | MEDLINE | ID: covidwho-815925
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel human respiratory viral infection that has rapidly progressed into a pandemic, causing significant morbidity and mortality. Blood clotting disorders and acute respiratory failure have surfaced as the major complications among the severe cases of coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 infection. Remarkably, more than 70% of deaths related to COVID-19 are attributed to clotting-associated complications such as pulmonary embolism, strokes and multi-organ failure. These vascular complications have been confirmed by autopsy. This study summarizes the current understanding and explains the possible mechanisms of the blood clotting disorder, emphasizing the role of (1) hypoxia-related activation of coagulation factors like tissue factor, a significant player in triggering coagulation cascade, (2) cytokine storm and activation of neutrophils and the release of neutrophil extracellular traps and (3) immobility and ICU related risk factors.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Respiratory Insufficiency / Disseminated Intravascular Coagulation / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Hypoxia Type of study: Prognostic study Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2177

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pulmonary Embolism / Respiratory Insufficiency / Disseminated Intravascular Coagulation / Cytokine Release Syndrome / SARS-CoV-2 / COVID-19 / Hypoxia Type of study: Prognostic study Language: English Journal: Rev Med Virol Journal subject: Virology Year: 2021 Document Type: Article Affiliation country: Rmv.2177