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Immunoserologic Detection and Diagnostic Relevance of Cross-Reactive Autoantibodies in Coronavirus Disease 2019 Patients.
Schiaffino, María Teresa; Di Natale, Marisa; García-Martínez, Elena; Navarro, Joaquín; Muñoz-Blanco, José Luis; Demelo-Rodríguez, Pablo; Sánchez-Mateos, Paloma.
  • Schiaffino MT; Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Di Natale M; Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • García-Martínez E; Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Navarro J; Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Muñoz-Blanco JL; Servicio de Neurología, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Demelo-Rodríguez P; Servicio de Medicina Interna, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
  • Sánchez-Mateos P; Servicio de Inmunología Clínica, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
J Infect Dis ; 222(9): 1439-1443, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-817413
ABSTRACT

BACKGROUND:

During the coronavirus disease 2019 (COVID-19) pandemic, we detected a new immunofluorescence (IF) pattern in serum autoantibody (autoAb) screening of laboratory-confirmed COVID-19 patients.

METHODS:

The IF pattern was composed of liver and gastric mucosa staining on rat kidney/liver/stomach sections.

RESULTS:

We describe 12 patients positive for the cross-reactive antibody, compared with a negative group of 43 hospitalized COVID-19 patients, finding association with either neurologic or thrombotic complications. In sequential pre- and post-COVID-19 serum samples, we confirmed autoAb seroconversion.

CONCLUSIONS:

Our data indicate that autoAb screening in COVID-19 patients may be easily performed by IF and alert for autoreactive-mediated complications such as thrombotic or neurologic events.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Autoantibodies / Thrombosis / Coronavirus Infections / Betacoronavirus / Nervous System Diseases Type of study: Diagnostic study / Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Autoantibodies / Thrombosis / Coronavirus Infections / Betacoronavirus / Nervous System Diseases Type of study: Diagnostic study / Experimental Studies / Observational study / Randomized controlled trials Topics: Long Covid Limits: Adult / Aged / Animals / Female / Humans / Male / Middle aged / Young adult Language: English Journal: J Infect Dis Year: 2020 Document Type: Article Affiliation country: Infdis