Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.
J Allergy Clin Immunol Pract
; 8(2): 588-595.e4, 2020 02.
Article
in English
| MEDLINE | ID: covidwho-822716
ABSTRACT
BACKGROUND:
Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types.OBJECTIVE:
To study whether RSV or RV types are differentially associated with the future use of asthma control medication.METHODS:
Over 2 consecutive winter seasons (2008-2010), we enrolled 408 children hospitalized for bronchiolitis at age less than 24 months into a prospective, 3-center, 4-year follow-up study in Finland. Virus detection was performed by real-time reverse transcription PCR from nasal wash samples. Four years later, we examined current use of asthma control medication.RESULTS:
A total of 349 (86%) children completed the 4-year follow-up. At study entry, the median age was 7.5 months, and 42% had RSV, 29% RV, 2% both RSV and RV, and 27% non-RSV/-RV etiology. The children with RV-A (adjusted hazard ratio, 2.3; P = .01), RV-C (adjusted hazard ratio, 3.5; P < .001), and non-RSV/-RV (adjusted hazard ratio, 2.0; P = .004) bronchiolitis started the asthma control medication earlier than did children with RSV bronchiolitis. Four years later, 27% of patients used asthma control medication; both RV-A (adjusted odds ratio, 3.0; P = .03) and RV-C (adjusted odds ratio, 3.7; P < .001) etiology were associated with the current use of asthma medication. The highest risk was found among patients with RV-C, atopic dermatitis, and fever (adjusted odds ratio, 5.0; P = .03).CONCLUSIONS:
Severe bronchiolitis caused by RV-A and RV-C was associated with earlier initiation and prolonged use of asthma control medication. The risk was especially high when bronchiolitis was associated with RV-C, atopic dermatitis, and fever.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Asthma
/
Rhinovirus
/
Bronchiolitis
/
Picornaviridae Infections
/
Influenza A Virus, H1N1 Subtype
Type of study:
Cohort study
/
Etiology study
/
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Child
/
Child, preschool
/
Humans
/
Infant
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
J Allergy Clin Immunol Pract
Year:
2020
Document Type:
Article
Affiliation country:
J.jaip.2019.08.043
Similar
MEDLINE
...
LILACS
LIS