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Rhinovirus Type in Severe Bronchiolitis and the Development of Asthma.
Bergroth, Eija; Aakula, Matilda; Elenius, Varpu; Remes, Sami; Piippo-Savolainen, Eija; Korppi, Matti; Piedra, Pedro A; Bochkov, Yury A; Gern, James E; Camargo, Carlos A; Jartti, Tuomas.
  • Bergroth E; Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland; Department of Pediatrics, Central Hospital of Central Finland, Jyväskylä, Finland.
  • Aakula M; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
  • Elenius V; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland.
  • Remes S; Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
  • Piippo-Savolainen E; Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland.
  • Korppi M; Center for Child Health Research, University of Tampere, Tampere, Finland; Tampere University Hospital, Tampere, Finland.
  • Piedra PA; Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, Texas.
  • Bochkov YA; Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
  • Gern JE; Departments of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wis.
  • Camargo CA; Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Mass.
  • Jartti T; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: tuomas.jartti@utu.fi.
J Allergy Clin Immunol Pract ; 8(2): 588-595.e4, 2020 02.
Article in English | MEDLINE | ID: covidwho-822716
ABSTRACT

BACKGROUND:

Respiratory syncytial virus (RSV)- and rhinovirus (RV)-induced bronchiolitis are associated with an increased risk of asthma, but more detailed information is needed on virus types.

OBJECTIVE:

To study whether RSV or RV types are differentially associated with the future use of asthma control medication.

METHODS:

Over 2 consecutive winter seasons (2008-2010), we enrolled 408 children hospitalized for bronchiolitis at age less than 24 months into a prospective, 3-center, 4-year follow-up study in Finland. Virus detection was performed by real-time reverse transcription PCR from nasal wash samples. Four years later, we examined current use of asthma control medication.

RESULTS:

A total of 349 (86%) children completed the 4-year follow-up. At study entry, the median age was 7.5 months, and 42% had RSV, 29% RV, 2% both RSV and RV, and 27% non-RSV/-RV etiology. The children with RV-A (adjusted hazard ratio, 2.3; P = .01), RV-C (adjusted hazard ratio, 3.5; P < .001), and non-RSV/-RV (adjusted hazard ratio, 2.0; P = .004) bronchiolitis started the asthma control medication earlier than did children with RSV bronchiolitis. Four years later, 27% of patients used asthma control medication; both RV-A (adjusted odds ratio, 3.0; P = .03) and RV-C (adjusted odds ratio, 3.7; P < .001) etiology were associated with the current use of asthma medication. The highest risk was found among patients with RV-C, atopic dermatitis, and fever (adjusted odds ratio, 5.0; P = .03).

CONCLUSIONS:

Severe bronchiolitis caused by RV-A and RV-C was associated with earlier initiation and prolonged use of asthma control medication. The risk was especially high when bronchiolitis was associated with RV-C, atopic dermatitis, and fever.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Rhinovirus / Bronchiolitis / Picornaviridae Infections / Influenza A Virus, H1N1 Subtype Type of study: Cohort study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Child / Child, preschool / Humans / Infant / Male Country/Region as subject: Europa Language: English Journal: J Allergy Clin Immunol Pract Year: 2020 Document Type: Article Affiliation country: J.jaip.2019.08.043

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Asthma / Rhinovirus / Bronchiolitis / Picornaviridae Infections / Influenza A Virus, H1N1 Subtype Type of study: Cohort study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Child / Child, preschool / Humans / Infant / Male Country/Region as subject: Europa Language: English Journal: J Allergy Clin Immunol Pract Year: 2020 Document Type: Article Affiliation country: J.jaip.2019.08.043