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Cellular Mechanisms of Melatonin: Insight from Neurodegenerative Diseases.
Chen, Dongmei; Zhang, Tao; Lee, Tae Ho.
  • Chen D; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, Fujian, China.
  • Zhang T; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, Fujian, China.
  • Lee TH; Fujian Key Laboratory for Translational Research in Cancer and Neurodegenerative Diseases, Institute for Translational Medicine, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350122, Fujian, China.
Biomolecules ; 10(8)2020 08 07.
Article in English | MEDLINE | ID: covidwho-823584
Semantic information from SemMedBD (by NLM)
1. Neurodegenerative Disorders CAUSES Cessation of life
Subject
Neurodegenerative Disorders
Predicate
CAUSES
Object
Cessation of life
2. Brain LOCATION_OF melatonin
Subject
Brain
Predicate
LOCATION_OF
Object
melatonin
3. Free Radicals DISRUPTS Oxidation
Subject
Free Radicals
Predicate
DISRUPTS
Object
Oxidation
4. melatonin AFFECTS Neuroprotection
Subject
melatonin
Predicate
AFFECTS
Object
Neuroprotection
5. melatonin TREATS Neurodegenerative Disorders
Subject
melatonin
Predicate
TREATS
Object
Neurodegenerative Disorders
6. melatonin TREATS Patients
Subject
melatonin
Predicate
TREATS
Object
Patients
7. Neurodegenerative Disorders PROCESS_OF Patients
Subject
Neurodegenerative Disorders
Predicate
PROCESS_OF
Object
Patients
8. melatonin ASSOCIATED_WITH Neurodegenerative Disorders
Subject
melatonin
Predicate
ASSOCIATED_WITH
Object
Neurodegenerative Disorders
9. Neurodegenerative Disorders CAUSES Cessation of life
Subject
Neurodegenerative Disorders
Predicate
CAUSES
Object
Cessation of life
10. Brain LOCATION_OF melatonin
Subject
Brain
Predicate
LOCATION_OF
Object
melatonin
11. Free Radicals DISRUPTS Oxidation
Subject
Free Radicals
Predicate
DISRUPTS
Object
Oxidation
12. melatonin AFFECTS Neuroprotection
Subject
melatonin
Predicate
AFFECTS
Object
Neuroprotection
13. melatonin TREATS Neurodegenerative Disorders
Subject
melatonin
Predicate
TREATS
Object
Neurodegenerative Disorders
14. melatonin TREATS Patients
Subject
melatonin
Predicate
TREATS
Object
Patients
15. Neurodegenerative Disorders PROCESS_OF Patients
Subject
Neurodegenerative Disorders
Predicate
PROCESS_OF
Object
Patients
16. melatonin ASSOCIATED_WITH Neurodegenerative Disorders
Subject
melatonin
Predicate
ASSOCIATED_WITH
Object
Neurodegenerative Disorders
ABSTRACT
Neurodegenerative diseases are the second most common cause of death and characterized by progressive impairments in movement or mental functioning in the central or peripheral nervous system. The prevention of neurodegenerative disorders has become an emerging public health challenge for our society. Melatonin, a pineal hormone, has various physiological functions in the brain, including regulating circadian rhythms, clearing free radicals, inhibiting biomolecular oxidation, and suppressing neuroinflammation. Cumulative evidence indicates that melatonin has a wide range of neuroprotective roles by regulating pathophysiological mechanisms and signaling pathways. Moreover, melatonin levels are decreased in patients with neurodegenerative diseases. In this review, we summarize current knowledge on the regulation, molecular mechanisms and biological functions of melatonin in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, vascular dementia and multiple sclerosis. We also discuss the clinical application of melatonin in neurodegenerative disorders. This information will lead to a better understanding of the regulation of melatonin in the brain and provide therapeutic options for the treatment of various neurodegenerative diseases.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Circadian Rhythm / Oxidative Stress / Neurodegenerative Diseases / Melatonin Topics: Variants Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Biom10081158

Full text: Available Collection: International databases Database: MEDLINE Main subject: Circadian Rhythm / Oxidative Stress / Neurodegenerative Diseases / Melatonin Topics: Variants Limits: Animals / Humans Language: English Year: 2020 Document Type: Article Affiliation country: Biom10081158