Your browser doesn't support javascript.
SUMO and Cytoplasmic RNA Viruses: From Enemies to Best Friends.
El Motiam, Ahmed; Vidal, Santiago; Seoane, Rocío; Bouzaher, Yanis H; González-Santamaría, José; Rivas, Carmen.
  • El Motiam A; Centro Singular en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
  • Vidal S; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • Seoane R; Centro Singular en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
  • Bouzaher YH; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
  • González-Santamaría J; Centro Singular en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidad de Santiago de Compostela, Santiago de Compostela, Spain.
  • Rivas C; Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.
Adv Exp Med Biol ; 1233: 263-277, 2020.
Article in English | MEDLINE | ID: covidwho-824704
ABSTRACT
SUMO is a ubiquitin-like protein that covalently binds to lysine residues of target proteins and regulates many biological processes such as protein subcellular localization or stability, transcription, DNA repair, innate immunity, or antiviral defense. SUMO has a critical role in the signaling pathway governing type I interferon (IFN) production, and among the SUMOylation substrates are many IFN-induced proteins. The overall effect of IFN is increasing global SUMOylation, pointing to SUMO as part of the antiviral stress response. Viral agents have developed different mechanisms to counteract the antiviral activities exerted by SUMO, and some viruses have evolved to exploit the host SUMOylation machinery to modify their own proteins. The exploitation of SUMO has been mainly linked to nuclear replicating viruses due to the predominant nuclear localization of SUMO proteins and enzymes involved in SUMOylation. However, SUMOylation of numerous viral proteins encoded by RNA viruses replicating at the cytoplasm has been lately described. Whether nuclear localization of these viral proteins is required for their SUMOylation is unclear. Here, we summarize the studies on exploitation of SUMOylation by cytoplasmic RNA viruses and discuss about the requirement for nuclear localization of their proteins.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / Viral Proteins / Cytoplasm / Small Ubiquitin-Related Modifier Proteins Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2020 Document Type: Article Affiliation country: 978-3-030-38266-7_11

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: RNA Viruses / Viral Proteins / Cytoplasm / Small Ubiquitin-Related Modifier Proteins Limits: Humans Language: English Journal: Adv Exp Med Biol Year: 2020 Document Type: Article Affiliation country: 978-3-030-38266-7_11