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Effect of essential oils on the immune response to some viral vaccines in broiler chickens, with special reference to Newcastle disease virus.
El-Shall, Nahed A; Shewita, Ramadan S; Abd El-Hack, Mohamed E; AlKahtane, Abdullah; Alarifi, Saud; Alkahtani, Saad; Abdel-Daim, Mohamed M; Sedeik, Mahmoud E.
  • El-Shall NA; Department of Poultry and Fish diseases, Faculty of Veterinary Medicine, Alexandria University, Edfina, Elbehira 22758, Egypt. Electronic address: nahed.abdelgawad@alexu.edu.eg.
  • Shewita RS; Department of Nutrition and Clinical Nutrition, Faculty of Veterinary Medicine, Alexandria University, Elbehira 22758, Egypt.
  • Abd El-Hack ME; Department of Poultry, Faculty of Agriculture, Zagazig University, Zagazig 44511, Egypt. Electronic address: dr.mohamed.e.abdalhaq@gmail.com.
  • AlKahtane A; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Alarifi S; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Alkahtani S; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Abdel-Daim MM; Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Pharmacology Department, Faculty of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt.
  • Sedeik ME; Department of Poultry and Fish diseases, Faculty of Veterinary Medicine, Alexandria University, Edfina, Elbehira 22758, Egypt.
Poult Sci ; 99(6): 2944-2954, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-824735
Semantic information from SemMedBD (by NLM)
1. Immune response PROCESS_OF Broiler chicken
Subject
Immune response
Predicate
PROCESS_OF
Object
Broiler chicken
2. Oil AFFECTS C0301872
Subject
Oil
Predicate
AFFECTS
Object
C0301872
3. Vaccines INTERACTS_WITH EOS
Subject
Vaccines
Predicate
INTERACTS_WITH
Object
EOS
4. Newcastle disease vaccine DISRUPTS Hemagglutination
Subject
Newcastle disease vaccine
Predicate
DISRUPTS
Object
Hemagglutination
5. Antibody titer measurement USES Enzyme-Linked Immunosorbent Assay
Subject
Antibody titer measurement
Predicate
USES
Object
Enzyme-Linked Immunosorbent Assay
6. Immune response PROCESS_OF Broiler chicken
Subject
Immune response
Predicate
PROCESS_OF
Object
Broiler chicken
7. Oils, Volatile AFFECTS Immune response
Subject
Oils, Volatile
Predicate
AFFECTS
Object
Immune response
8. Vaccines INTERACTS_WITH EOS
Subject
Vaccines
Predicate
INTERACTS_WITH
Object
EOS
9. Newcastle disease vaccine DISRUPTS Hemagglutination
Subject
Newcastle disease vaccine
Predicate
DISRUPTS
Object
Hemagglutination
10. Antibody titer measurement USES Enzyme-Linked Immunosorbent Assay
Subject
Antibody titer measurement
Predicate
USES
Object
Enzyme-Linked Immunosorbent Assay
ABSTRACT
This trial assessed the efficacy of a commercial essential oil (EO) product on the immune response to vaccination against Newcastle disease (ND) and subsequent challenge with virulent ND virus genotype VII (vNDv genotype VII) by using the following experimental groups of broiler chickens (Each group had 21 birds with 3 replicates in each, n = 7) NC (negative control), PC (positive control), VC (vaccinated), and VTC (vaccinated and treated with EOs). Moreover, in a trial to study the effect of EOs on vNDv genotype VII in vivo as a preventive or therapeutic measure, 2 additional ND-vaccinated groups were used (PRV medicated 1 D before vNDv challenge for 5 D; and TTT medicated 2 D after vNDv challenge for 5 D). In addition, the immune-modulatory effect of EOs on the avian influenza (AI), infectious bronchitis (IB), and infectious bursal disease (IBD) vaccines was assessed through the serological response. The use of EOs along with administration of ND vaccines (VTC) revealed a lower mortality rate (42.86%), clinical signs, and postmortem lesion score (11) than ND vaccines alone (VC) (52.28% mortality and score 15), in addition to lower hemagglutination inhibition (P < 0.05) (6.5 ± 0.46) and viral shedding (10 log 2.28 ± 0.24) titres 1 wk after challenge in comparison with VC (8.63 ± 0.65 and 10 log 3.29 ± 0.72, respectively). Nevertheless, the EOs mixture (VTC) (1952 ± 28.82) did not significantly (P > 0.05) improve growth performance compared with the nontreated birds (NC and VC) (1970 ± 19.56 and 1904 ± 38.66). EOs showed an antiviral effect on vNDv in vivo (in chickens) as a preventive measure (PRV) as well as some therapeutic effect (TTT) through decreasing the viral shedding titres (loNC0), mortality rate, and severity of clinical signs and postmortem lesions, in addition to serum malondialdhyde level. Regarding the other viruses, the EOs mixture did not improve the immune response to the AI and IB vaccines but significantly (P < 0.05) increased the ELISA antibody titre for IBD virus at the 28th D of age (2,108 ± 341.05). The studied EOs mixture showed an immune-stimulating response to ND and IBD vaccines, antiviral effect against ND virus, especially if administered before the challenge; however, it did not have a growth-promoting effect.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Poultry Diseases / Newcastle disease virus / Oils, Volatile / Viral Vaccines / Chickens / Immunity, Humoral / Newcastle Disease Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Journal: Poult Sci Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Poultry Diseases / Newcastle disease virus / Oils, Volatile / Viral Vaccines / Chickens / Immunity, Humoral / Newcastle Disease Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Animals Language: English Journal: Poult Sci Year: 2020 Document Type: Article