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Influenza vaccine effectiveness and disease burden in children and adolescents with sickle cell disease: 2012-2017.
Kao, Carol M; Lai, Kristina; McAteer, John M; Elmontser, Mohnd; Quincer, Elizabeth M; Yee, Marianne E M; Tippet, Ashley; Jerris, Robert C; Lane, Peter A; Anderson, Evan J; Bakshi, Nitya; Yildirim, Inci.
  • Kao CM; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
  • Lai K; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.
  • McAteer JM; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
  • Elmontser M; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
  • Quincer EM; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
  • Yee MEM; Emory University School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Atlanta, Georgia.
  • Tippet A; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.
  • Jerris RC; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
  • Lane PA; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
  • Anderson EJ; Emory University School of Medicine, Department of Pediatrics, Division of Hematology/Oncology, Atlanta, Georgia.
  • Bakshi N; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, Georgia.
  • Yildirim I; Emory University School of Medicine, Department of Pediatrics, Division of Infectious Diseases, Atlanta, Georgia.
Pediatr Blood Cancer ; 67(8): e28358, 2020 08.
Article in English | MEDLINE | ID: covidwho-826880
ABSTRACT

BACKGROUND:

Data are limited on the burden of influenza and seasonal influenza vaccine effectiveness (VE) in children with sickle cell disease (SCD).

METHODS:

We used a prospectively collected clinical registry of SCD patients 6 months to 21 years of age to determine the influenza cases per 100 patient-years, vaccination rates, and a test-negative case-control study design to estimate influenza VE against medically attended laboratory-confirmed influenza infection. Influenza-positive cases were randomly matched to test-negative controls on age and influenza season in 11 ratio. We used adjusted logistic regression models to compare odds ratio (OR) of vaccination in cases to controls. We calculated VE as [100% × (1 - adjusted OR)] and computed 95% confidence intervals (CIs) around the estimate.

RESULTS:

There were 1037 children with SCD who were tested for influenza, 307 children (29.6%) had at least one influenza infection (338 infections, incidence rate 3.7 per 100 person-years; 95% CI, 3.4-4.1) and 56.2% of those tested received annual influenza vaccine. Overall VE pooled over five seasons was 22.3% (95% CI, -7.3% to 43.7%). Adjusted VE estimates ranged from 39.7% (95% CI, -70.1% to 78.6%) in 2015/2016 to -5.9% (95% CI, -88.4% to 40.4%) in the 2016/17 seasons. Influenza VE varied by age and was highest in children 1-5 years of age (66.6%; 95% CI, 30.3-84.0). Adjusted VE against acute chest syndrome during influenza infection was 39.4% (95% CI, -113.0 to 82.8%).

CONCLUSIONS:

Influenza VE in patients with SCD varies by season and age. Multicenter prospective studies are needed to better establish and monitor influenza VE among children with SCD.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Vaccination / Cost of Illness / Influenza, Human / Acute Chest Syndrome Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2020 Document Type: Article Affiliation country: Pbc.28358

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza Vaccines / Vaccination / Cost of Illness / Influenza, Human / Acute Chest Syndrome Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Vaccines Limits: Adolescent / Adult / Child / Child, preschool / Female / Humans / Infant / Male Language: English Journal: Pediatr Blood Cancer Journal subject: Hematology / Neoplasms / Pediatrics Year: 2020 Document Type: Article Affiliation country: Pbc.28358