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Ultraviolet Irradiation Enhances the Microbicidal Activity of Silver Nanoparticles by Hydroxyl Radicals.
Nakamura, Shingo; Ando, Naoko; Sato, Masahiro; Ishihara, Masayuki.
  • Nakamura S; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
  • Ando N; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
  • Sato M; Section of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.
  • Ishihara M; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Int J Mol Sci ; 21(9)2020 Apr 30.
Article in English | MEDLINE | ID: covidwho-829127
ABSTRACT
It is known that silver has microbicidal qualities; even at a low concentration, silver is active against many kinds of bacteria. Silver nanoparticles (AgNPs) have been extensively studied for a wide range of applications. Alternately, the toxicity of silver to human cells is considerably lower than that to bacteria. Recent studies have shown that AgNPs also have antiviral activity. We found that large amounts of hydroxyl radicals-highly reactive molecular species-are generated when AgNPs are irradiated with ultraviolet (UV) radiation with a wavelength of 365 nm, classified as ultraviolet A (UVA). In this study, we used electron spin resonance direct detection to confirm that UV irradiation of AgNPs produced rapid generation of hydroxyl radicals. As hydroxyl radicals are known to degrade bacteria, viruses, and some chemicals, the enhancement of the microbicidal activity of AgNPs by UV radiation could be valuable for the protection of healthcare workers and the prevention of the spread of infectious diseases.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Silver / Ultraviolet Rays / Hydroxyl Radical / Metal Nanoparticles Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21093204

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Silver / Ultraviolet Rays / Hydroxyl Radical / Metal Nanoparticles Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Ijms21093204