COVID-19 Vaccines: Particulate Alum via Pickering Emulsion for an Enhanced COVID-19 Vaccine Adjuvant (Adv. Mater. 40/2020)

ABSTRACT

For enhanced COVID-19 vaccines, in article number 2004210, Yufei Xia, Guanghui Ma, and co-workers pack licensed alum on a squalene/water interphase. Thereby, this century-old adjuvant ?travels through time? in a new form of alum-stabilized Pickering emulsion (PAPE), which not only inherits the clinically acknowledged biosafety, but also demonstrates enhanced cellular uptake and cross-presentation of antigens for potent humoral and cellular responses.