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A Systems Biology Workflow for Drug and Vaccine Repurposing: Identifying Small-Molecule BCG Mimics to Reduce or Prevent COVID-19 Mortality.
Hajjo, Rima; Tropsha, Alexander.
  • Hajjo R; Department of Pharmacy - Computational Chemical Biology, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, P.O. Box 130, Amman, 11733, Jordan. rhajjo@gmail.com.
  • Tropsha A; Laboratory for Molecular Modeling, UNC Eshelman School of Pharmacy, UNC Chapel Hill, Chapel Hill, North Carolina, 27599, USA.
Pharm Res ; 37(11): 212, 2020 Oct 06.
Article in English | MEDLINE | ID: covidwho-834023
ABSTRACT

PURPOSE:

Coronavirus disease 2019 (COVID-19) is expected to continue to cause worldwide fatalities until the World population develops 'herd immunity', or until a vaccine is developed and used as a prevention. Meanwhile, there is an urgent need to identify alternative means of antiviral defense. Bacillus Calmette-Guérin (BCG) vaccine that has been recognized for its off-target beneficial effects on the immune system can be exploited to boast immunity and protect from emerging novel viruses.

METHODS:

We developed and employed a systems biology workflow capable of identifying small-molecule antiviral drugs and vaccines that can boast immunity and affect a wide variety of viral disease pathways to protect from the fatal consequences of emerging viruses.

RESULTS:

Our analysis demonstrates that BCG vaccine affects the production and maturation of naïve T cells resulting in enhanced, long-lasting trained innate immune responses that can provide protection against novel viruses. We have identified small-molecule BCG mimics, including antiviral drugs such as raltegravir and lopinavir as high confidence hits. Strikingly, our top hits emetine and lopinavir were independently validated by recent experimental findings that these compounds inhibit the growth of SARS-CoV-2 in vitro.

CONCLUSIONS:

Our results provide systems biology support for using BCG and small-molecule BCG mimics as putative vaccine and drug candidates against emergent viruses including SARS-CoV-2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / BCG Vaccine / Viral Vaccines / Coronavirus Infections / Biomimetic Materials / Small Molecule Libraries / Drug Repositioning / Pandemics Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Pharm Res Year: 2020 Document Type: Article Affiliation country: S11095-020-02930-9

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / BCG Vaccine / Viral Vaccines / Coronavirus Infections / Biomimetic Materials / Small Molecule Libraries / Drug Repositioning / Pandemics Type of study: Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Pharm Res Year: 2020 Document Type: Article Affiliation country: S11095-020-02930-9