The Complement C5a-C5aR1 GPCR Axis in COVID-19 Therapeutics.

Woodruff, Trent M; Shukla, Arun K

Woodruff, Trent M; Shukla, Arun K.

Woodruff TM; The School of Biomedical Sciences, Faculty of Medicine, The University of Queensland, Brisbane 4072, Australia; Queensland Brain Institute, The University of Queensland, Brisbane 4072, Australia. Electronic address: t.woodruff@uq.edu.au.
Shukla AK; Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur 208016, India. Electronic address: arshukla@iitk.ac.in.

Trends Immunol ; 41(11): 965-967, 2020 11.

Article in English | MEDLINE | ID: covidwho-834446

ABSTRACT

ABSTRACT

The current pandemic of coronavirus disease (COVID-19) caused by SARS-CoV-2 is a significant global health challenge. A recent study by Carvelli and colleagues now demonstrates the involvement of complement C5a and its receptor C5aR1 in disease progression and suggests that blockade of the C5a-C5aR1 axis may represent a potential therapeutic strategy against COVID-19.

Subject(s)

Betacoronavirus/immunology; Complement C5a/immunology; Coronavirus Infections/immunology; Pneumonia, Viral/immunology; Receptor, Anaphylatoxin C5a/immunology; Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacology; Betacoronavirus/drug effects; Betacoronavirus/physiology; COVID-19; Complement C5a/metabolism; Coronavirus Infections/therapy; Coronavirus Infections/virology; Disease Models, Animal; Humans; Pandemics; Pneumonia, Viral/therapy; Pneumonia, Viral/virology; Receptor, Anaphylatoxin C5a/metabolism; Receptors, G-Protein-Coupled/immunology; Receptors, G-Protein-Coupled/metabolism; SARS-CoV-2; Signal Transduction/drug effects; Signal Transduction/immunology

Keywords

COVID-19; GPCRs; SARS-CoV-2; cellular signaling; complement system; drug discovery

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Complement C5a / Coronavirus Infections / Receptor, Anaphylatoxin C5a / Betacoronavirus Limits: Animals / Humans Language: English Journal: Trends Immunol Journal subject: Allergy and Immunology Year: 2020 Document Type: Article

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