Collapsing Focal Segmental Glomerulosclerosis and Acute Oxalate Nephropathy in a Patient With COVID-19: A Double Whammy.
J Investig Med High Impact Case Rep
; 8: 2324709620963635, 2020.
Article
in English
| MEDLINE | ID: covidwho-835773
ABSTRACT
As COVID-19 (coronavirus disease 2019) spreads across the world multiple therapeutic interventions have been tried to reduce morbidity and mortality. We describe a case of collapsing focal sclerosing glomerulosclerosis (FSGS) and acute oxalate nephropathy in a patient treated with high-dose intravenous vitamin C for severe COVID-19 infection. Collapsing FSGS has been described in patients with COVID-19 infection associated with APOL-1; however, this case had collapsing FSGS developing in low-risk heterozygous APOL-1 variant, and we postulate that the intensity of the COVID-19 cytokine storm overwhelmed the protective state of APOL-1 heterozygosity. This case illustrates the importance of assessing the risk and benefit of planned therapeutic interventions on a case-by-case basis especially when there are still so many unknowns in the management of COVID-19 infection. Strong consideration should be given for performing a renal biopsy in patients who develop multifactorial acute kidney injury.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Oxalates
/
Pneumonia, Viral
/
Ascorbic Acid
/
Hyperoxaluria
/
Glomerulosclerosis, Focal Segmental
/
Coronavirus Infections
/
Betacoronavirus
/
Kidney Glomerulus
Type of study:
Case report
/
Diagnostic study
/
Observational study
/
Prognostic study
Topics:
Variants
Limits:
Humans
/
Male
/
Middle aged
Language:
English
Journal:
J Investig Med High Impact Case Rep
Year:
2020
Document Type:
Article
Affiliation country:
2324709620963635
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