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COVID-19 with repeated positive test results for SARS-CoV-2 by PCR and then negative test results twice during intensive care: a case report.
Kanamoto, Masafumi; Tobe, Masaru; Takazawa, Tomonori; Saito, Shigeru.
  • Kanamoto M; Department of Anesthesiology and Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa, Maebashi, Gunma, Japan. kanamoto@gunma-u.ac.jp.
  • Tobe M; Department of Anesthesiology and Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa, Maebashi, Gunma, Japan.
  • Takazawa T; Department of Anesthesiology and Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa, Maebashi, Gunma, Japan.
  • Saito S; Department of Anesthesiology and Intensive Care Unit, Gunma University Hospital, 3-39-15 Showa, Maebashi, Gunma, Japan.
J Med Case Rep ; 14(1): 191, 2020 Oct 07.
Article in English | MEDLINE | ID: covidwho-835873
Semantic information from SemMedBD (by NLM)
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6. 2019 novel coronavirus NEG_PROCESS_OF Male population group
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2019 novel coronavirus
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ABSTRACT

BACKGROUND:

Determining the infectiousness of patients with coronavirus disease 2019 is crucial for patient management. Medical staff usually refer to the results of reverse transcription polymerase chain reaction tests in conjunction with clinical symptoms and computed tomographic images. CASE PRESENTATION We report a case of a 62-year-old Japanese man who twice had positive and negative test results by polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 over 48 days of hospitalization, including in intensive care. His respiratory symptoms and computed tomographic imaging findings consistent with coronavirus disease 2019 improved following initial intensive care, and the result of his polymerase chain reaction test became negative 3 days before discharge from the intensive care unit. However, 4 days after this first negative result, his polymerase chain reaction test result was positive again, and another 4 days later, he had a negative result once more. Eight days after the second polymerase chain reaction negative test result, the patient's test result again became positive. Finally, his polymerase chain reaction results were negative 43 days after his first hospitalization.

CONCLUSIONS:

This case emphasizes the importance of repeat polymerase chain reaction testing and diagnosis based on multiple criteria, including clinical symptoms and computed tomographic imaging findings. Clinical staff should consider that a negative result by polymerase chain reaction does not necessarily certify complete coronavirus disease 2019 recovery.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Pandemics / Symptom Assessment / Betacoronavirus / Lung Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: J Med Case Rep Year: 2020 Document Type: Article Affiliation country: S13256-020-02534-2

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Clinical Laboratory Techniques / Pandemics / Symptom Assessment / Betacoronavirus / Lung Type of study: Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: J Med Case Rep Year: 2020 Document Type: Article Affiliation country: S13256-020-02534-2