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[Management of the thrombotic risk associated with COVID-19: what is the role of the hemostasis laboratory?] / Apport du laboratoire d'hémostase dans la gestion du risque thrombotique associé au Covid-19.
Hardy, Michael; Douxfils, Jonathan; Dogné, Jean-Michel; Lessire, Sarah; Chatelain, Bernard; Testa, Sophie; Gouin-Thibault, Isabelle; Gruel, Yves; Lecompte, Thomas; Mullier, François.
  • Hardy M; Laboratoire d'hématologie, Namur Thrombosis and Hemostasis Center (NTHC), Université catholique de Louvain, CHU UCL Namur, Yvoir, Belgique, Service d'anesthésiologie, Namur Thrombosis and Hemostasis Center (NTHC), Université catholique de Louvain, CHU UCL Namur, Yvoir, Belgique.
  • Douxfils J; Département de pharmacie, Namur Thrombosis and Hemostasis Center (NTHC), Université de Namur, Namur, Belgique, Qualiblood s.a., Namur, Belgique.
  • Dogné JM; Département de pharmacie, Namur Thrombosis and Hemostasis Center (NTHC), Université de Namur, Namur, Belgique.
  • Lessire S; Service d'anesthésiologie, Namur Thrombosis and Hemostasis Center (NTHC), Université catholique de Louvain, CHU UCL Namur, Yvoir, Belgique.
  • Chatelain B; Laboratoire d'hématologie, Namur Thrombosis and Hemostasis Center (NTHC), Université catholique de Louvain, CHU UCL Namur, Yvoir, Belgique.
  • Testa S; Haemostasis and Thrombosis Center, Cremona Hospital, Crémone, Italie.
  • Gouin-Thibault I; Inserm, CIC 1414 (Centre d'investigation clinique de Rennes), Université de Rennes, CHU de Rennes, Département d'hématologie biologique, Rennes, France.
  • Gruel Y; Laboratoire d'hématologie-hémostase, CHRU de Tours, Hôpital Trousseau, Tours, France.
  • Lecompte T; Département de médecine, Hôpitaux universitaires de Genève, Service d'angiologie et d'hémostase et Faculté de médecine Geneva Platelet Group (GpG), Université de Genève, Genève, Suisse.
  • Mullier F; Laboratoire d'hématologie, Namur Thrombosis and Hemostasis Center (NTHC), Université catholique de Louvain, CHU UCL Namur, Yvoir, Belgique.
Ann Biol Clin (Paris) ; 78(5): 471-481, 2020 10 01.
Article in French | MEDLINE | ID: covidwho-836030
ABSTRACT
COVID-19 is associated with disturbances of hemostasis in the laboratory and an increased thrombotic risk. Routine laboratory tests - activated partial thromboplastin time (aPTT), prothrombin time, Clauss fibrinogen and D-dimers levels measurement - are used for the evaluation of the thrombotic risk and the monitoring of hemostasis, but are subject to several drawbacks that may affect the reliability and clinical relevance of the delivered results. Another challenge for the hemostasis laboratory is the monitoring of heparin treatment. For instance, the issue of the monitoring of unfractionated heparin remains debated, the more so when there is a tremendous inflammatory response. This brief review considers the role of laboratory tests of hemostasis in the management of COVID-19 and discusses their main limitations to be kept in mind.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Coronavirus Infections / Hemostasis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: French Journal: Ann Biol Clin (Paris) Year: 2020 Document Type: Article Affiliation country: Abc.2020.1581

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Thrombosis / Coronavirus Infections / Hemostasis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: French Journal: Ann Biol Clin (Paris) Year: 2020 Document Type: Article Affiliation country: Abc.2020.1581