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Challenges for Mesenchymal Stem Cell-Based Therapy for COVID-19.
Li, Chenghai; Zhao, Hua; Wang, Bin.
  • Li C; Stem Cell Program of Clinical Research Center, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China.
  • Zhao H; Henan Key Laboratory of Stem Cell Differentiation and Modification, Zhengzhou 450003, People's Republic of China.
  • Wang B; Reproductive Medicine Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Zhengzhou 450003, People's Republic of China.
Drug Des Devel Ther ; 14: 3995-4001, 2020.
Article in English | MEDLINE | ID: covidwho-836051
ABSTRACT
The coronavirus disease 2019 (COVID-19) global pandemic continues and antiviral agents and vaccines are currently under investigation. Mesenchymal stem cell (MSC)-based therapy can be a suitable option for management of patients with COVID-19 at the urgent time of virus outbreak. Currently, MSCs are being explored against the novel infectious disease due to their therapeutic properties of anti-inflammation, immunomodulation and tissue repair and regeneration, albeit the precise mechanisms of MSC action toward COVID-19 remain unclear. To date, rigorous results from clinical trials using MSCs in human have been weakly positive. The pervasive uncertainty of using MSC therapeutic products as an effective combatant against COVID-19 requires rigorous resolution on several fronts, including MSC fate after infusion, safety issue, homing capability, and MSC resistance to the disease microenvironment. Focusing on these facets, a few important ones will be critically analyzed and addressed in this article for the development of safe and effective MSC-based therapies for COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Mesenchymal Stem Cell Transplantation / Betacoronavirus Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Drug Des Devel Ther Journal subject: Pharmacology / Drug Therapy Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Mesenchymal Stem Cell Transplantation / Betacoronavirus Type of study: Diagnostic study / Prognostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Drug Des Devel Ther Journal subject: Pharmacology / Drug Therapy Year: 2020 Document Type: Article