The long-standing history of Corynebacterium parvum, immunity, and viruses.
J Med Virol
; 92(11): 2429-2439, 2020 11.
Article
in English
| MEDLINE | ID: covidwho-838040
ABSTRACT
We report a review of all the experimental and clinical studies performed in the last 60 years on the antiviral activity of inactivated Corynebacterium parvum (Cutibacterium acnes). This bacterium has been originally investigated and used for its oncolytic properties linked to immunomodulating activity, but the interest to successfully prevent and treat bacterial, fungal, and viral infections and lethality, uprising the innate immunity barriers produced many experimental models and very few clinical studies. The dramatic defenseless situation due to impending CoViD-19 pandemic claims to exhume and highlight this aspecific strategy in preventive and therapeutic settings; as a matter of fact, no new or mutated virus can potentially escape to this strong innate immune surveillance strengthened by adequate C. parvum protocols.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Propionibacterium acnes
/
Virus Diseases
/
Immunity, Innate
/
Immunologic Factors
/
Immunologic Surveillance
Type of study:
Prognostic study
/
Randomized controlled trials
Limits:
Animals
/
Humans
Language:
English
Journal:
J Med Virol
Year:
2020
Document Type:
Article
Affiliation country:
Jmv.26100
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