Your browser doesn't support javascript.
Identifying Effective Antiviral Drugs Against SARS-CoV-2 by Drug Repositioning Through Virus-Drug Association Prediction.
Peng, Lihong; Tian, Xiongfei; Shen, Ling; Kuang, Ming; Li, Tianbao; Tian, Geng; Yang, Jialiang; Zhou, Liqian.
  • Peng L; School of Computer Science, Hunan University of Technology, Zhuzhou, China.
  • Tian X; School of Computer Science, Hunan University of Technology, Zhuzhou, China.
  • Shen L; School of Computer Science, Hunan University of Technology, Zhuzhou, China.
  • Kuang M; School of Computer Science, Hunan University of Technology, Zhuzhou, China.
  • Li T; Geneis (Beijing) Co., Ltd., Beijing, China.
  • Tian G; Geneis (Beijing) Co., Ltd., Beijing, China.
  • Yang J; Geneis (Beijing) Co., Ltd., Beijing, China.
  • Zhou L; School of Computer Science, Hunan University of Technology, Zhuzhou, China.
Front Genet ; 11: 577387, 2020.
Article in English | MEDLINE | ID: covidwho-840519
ABSTRACT
A new coronavirus called SARS-CoV-2 is rapidly spreading around the world. Over 16,558,289 infected cases with 656,093 deaths have been reported by July 29th, 2020, and it is urgent to identify effective antiviral treatment. In this study, potential antiviral drugs against SARS-CoV-2 were identified by drug repositioning through Virus-Drug Association (VDA) prediction. 96 VDAs between 11 types of viruses similar to SARS-CoV-2 and 78 small molecular drugs were extracted and a novel VDA identification model (VDA-RLSBN) was developed to find potential VDAs related to SARS-CoV-2. The model integrated the complete genome sequences of the viruses, the chemical structures of drugs, a regularized least squared classifier (RLS), a bipartite local model, and the neighbor association information. Compared with five state-of-the-art association prediction methods, VDA-RLSBN obtained the best AUC of 0.9085 and AUPR of 0.6630. Ribavirin was predicted to be the best small molecular drug, with a higher molecular binding energy of -6.39 kcal/mol with human angiotensin-converting enzyme 2 (ACE2), followed by remdesivir (-7.4 kcal/mol), mycophenolic acid (-5.35 kcal/mol), and chloroquine (-6.29 kcal/mol). Ribavirin, remdesivir, and chloroquine have been under clinical trials or supported by recent works. In addition, for the first time, our results suggested several antiviral drugs, such as FK506, with molecular binding energies of -11.06 and -10.1 kcal/mol with ACE2 and the spike protein, respectively, could be potentially used to prevent SARS-CoV-2 and remains to further validation. Drug repositioning through virus-drug association prediction can effectively find potential antiviral drugs against SARS-CoV-2.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Front Genet Year: 2020 Document Type: Article Affiliation country: Fgene.2020.577387

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study Language: English Journal: Front Genet Year: 2020 Document Type: Article Affiliation country: Fgene.2020.577387