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Comparative Anticoagulant and Thrombin Generation Inhibitory Profile of Heparin, Sulodexide and Its Components.
Siddiqui, Fakiha; Hoppensteadt, Debra; Bontekoe, Emily; Farooqui, Ambar; Jeske, Walter; Fareed, Jawed.
  • Siddiqui F; Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
  • Hoppensteadt D; Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
  • Bontekoe E; Department of Pharmacology and Neuroscience, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
  • Farooqui A; Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
  • Jeske W; Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
  • Fareed J; Department of Pathology and Laboratory Medicine, Cardiovascular Research Institute, Loyola University Chicago, Health Sciences Division, Maywood, IL, USA.
Clin Appl Thromb Hemost ; 26: 1076029620954913, 2020.
Article in English | MEDLINE | ID: covidwho-841480
Semantic information from SemMedBD (by NLM)
1. Dermatan Sulfate TREATS Disorder of vein
Subject
Dermatan Sulfate
Predicate
TREATS
Object
Disorder of vein
2. heparin TREATS Disorder of vein
Subject
heparin
Predicate
TREATS
Object
Disorder of vein
3. glucuronyl glucosamine glycan sulfate compared_with heparin
Subject
glucuronyl glucosamine glycan sulfate
Predicate
compared_with
Object
heparin
4. glucuronyl glucosamine glycan sulfate COEXISTS_WITH heparin
Subject
glucuronyl glucosamine glycan sulfate
Predicate
COEXISTS_WITH
Object
heparin
5. Anticoagulants COEXISTS_WITH heparin
Subject
Anticoagulants
Predicate
COEXISTS_WITH
Object
heparin
6. Dermatan Sulfate TREATS Disorder of vein
Subject
Dermatan Sulfate
Predicate
TREATS
Object
Disorder of vein
7. heparin TREATS Disorder of vein
Subject
heparin
Predicate
TREATS
Object
Disorder of vein
8. glucuronyl glucosamine glycan sulfate compared_with heparin
Subject
glucuronyl glucosamine glycan sulfate
Predicate
compared_with
Object
heparin
9. glucuronyl glucosamine glycan sulfate COEXISTS_WITH heparin
Subject
glucuronyl glucosamine glycan sulfate
Predicate
COEXISTS_WITH
Object
heparin
10. Anticoagulants COEXISTS_WITH heparin
Subject
Anticoagulants
Predicate
COEXISTS_WITH
Object
heparin
ABSTRACT

INTRODUCTION:

Sulodexide represents a mixture of fast-moving heparin (FMH) and dermatan sulfate (DS) and has been used for the management of venous diseases such as DVT and related disorders. The purpose of this study is to compare sulodexide and its components with unfractionated heparin (UFH) to determine its suitability for the indications in which UFH is used. MATERIALS AND

METHOD:

Active pharmaceutical ingredients (API) versions of sulodexide, FMH and DS were obtained from Alfasigma. API versions of UFH were obtained from Medefil Inc. Normal human citrated plasma was obtained from blood bank of the Loyola University Medical Center. Each of the individual agents were supplemented in plasma at a graded concentration of 0.0-10 µg/mL. Clotting assays (PiCT, aPTT, PT and TT), anti-Xa and anti-IIa and thrombin generation studies were carried out. Results were compiled as mean ± SD of 3 individual determination.

RESULT:

In the clot based (PiCT, aPTT and TT), anti-Xa and IIa assays, both the UFH and FMH produced stronger activities in these assays followed by sulodexide. DS did not show any anticoagulant activity. In the thrombin generation assay, FMH and UFH produced comparable inhibition of thrombin generation as measured by various parameters. Sulodexide was slightly weaker in this assay, whereas DS produced relatively weaker effects.

CONCLUSION:

In comparison to sulodexide, both UFH and FMH exhibit comparable anticoagulant activity despite differences in their molecular weight. These results suggest that sulodexide can be developed as a parenteral anticoagulant for indications in which UFH is used.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Thrombin / Glycosaminoglycans / Anticoagulants Type of study: Diagnostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: 1076029620954913

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Blood Coagulation / Thrombin / Glycosaminoglycans / Anticoagulants Type of study: Diagnostic study Limits: Humans Country/Region as subject: Europa Language: English Journal: Clin Appl Thromb Hemost Journal subject: Vascular Diseases Year: 2020 Document Type: Article Affiliation country: 1076029620954913