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A case of COVID-19 pneumonia successfully treated with favipiravir (Avigan) in which serum SARS-CoV-2 RNA detected by LAMP method was clinically useful.
Hirouchi, Takatomo; Ota, Shinichiro; Mashima, Dai; Boku, Ryuichi; Yoshida, Yuto; Iwata, Koki; Shinada, Kanako; Matsumoto, Takashi; Morikawa, Miwa; Sato, Takashi; Shinoda, Masahiro; Kamachi, Kenichi; Shinkai, Masaharu.
  • Hirouchi T; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
  • Ota S; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan. Electronic address: shin.ohta0915@gmail.com.
  • Mashima D; Department of Laboratory Testing, Tokyo Shinagawa Hospital, Japan.
  • Boku R; Department of Emergency Medicine, Tokyo Shinagawa Hospital, Japan.
  • Yoshida Y; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
  • Iwata K; Department of Emergency Medicine, Tokyo Shinagawa Hospital, Japan.
  • Shinada K; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
  • Matsumoto T; Department of Emergency Medicine, Tokyo Shinagawa Hospital, Japan.
  • Morikawa M; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
  • Sato T; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
  • Shinoda M; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
  • Kamachi K; Department of Emergency Medicine, Tokyo Shinagawa Hospital, Japan.
  • Shinkai M; Department of Respiratory Medicine, Tokyo Shinagawa Hospital, Japan.
J Infect Chemother ; 27(2): 379-383, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-844273
ABSTRACT
A 49-year-old Japanese male was managed by mechanical ventilation due to coronavirus disease 2019 (COVID-19) pneumonia. Favipiravir as an antiviral therapy, and anti-inflammatory treatment were administered. SARS-CoV-2 RNA was detected in serum by the loop-mediated isothermal amplification (LAMP) method on Day 9; favipiravir treatment was continued. On Day 13, negative serum RNA was confirmed, followed by mechanical ventilation was removed. On Day 23, LAMP negative was confirmed in nasopharynx, after that the patient discharged on Day 27. We could treat successfully for severe COVID-19 pneumonia based on the LAMP method. We consider this method will be useful in COVID-19 treatment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pyrazines / RNA, Viral / Amides / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: J.jiac.2020.10.011

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pyrazines / RNA, Viral / Amides / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans / Male / Middle aged Language: English Journal: J Infect Chemother Journal subject: Microbiology / Drug Therapy Year: 2021 Document Type: Article Affiliation country: J.jiac.2020.10.011