The therapeutic importance of acid-base balance.
Biochem Pharmacol
; 183: 114278, 2021 01.
Article
in English
| MEDLINE | ID: covidwho-845710
ABSTRACT
Baking soda and vinegar have been used as home remedies for generations and today we are only a mouse-click away from claims that baking soda, lemon juice, and apple cider vinegar are miracles cures for everything from cancer to COVID-19. Despite these specious claims, the therapeutic value of controlling acid-base balance is indisputable and is the basis of Food and Drug Administration-approved treatments for constipation, epilepsy, metabolic acidosis, and peptic ulcers. In this narrative review, we present evidence in support of the current and potential therapeutic value of countering local and systemic acid-base imbalances, several of which do in fact involve the administration of baking soda (sodium bicarbonate). Furthermore, we discuss the side effects of pharmaceuticals on acid-base balance as well as the influence of acid-base status on the pharmacokinetic properties of drugs. Our review considers all major organ systems as well as information relevant to several clinical specialties such as anesthesiology, infectious disease, oncology, dentistry, and surgery.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Acid-Base Equilibrium
/
Acid-Base Imbalance
Type of study:
Prognostic study
/
Reviews
Topics:
Traditional medicine
Limits:
Animals
/
Humans
Language:
English
Journal:
Biochem Pharmacol
Year:
2021
Document Type:
Article
Affiliation country:
J.bcp.2020.114278
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