COVID-19 vaccine and boosted immunity: Nothing ad interim to do?

Roncati, Luca; Vadalà, Maria; Corazzari, Veronica; Palmieri, Beniamino

Roncati, Luca; Vadalà, Maria; Corazzari, Veronica; Palmieri, Beniamino.

Roncati L; Institute of Pathology, University Hospital of Modena, Modena, Italy. Electronic address: roncati.luca@aou.mo.it.
Vadalà M; Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia, Modena, Italy; Second Opinion Medical Network, Modena, Italy.
Corazzari V; Second Opinion Medical Network, Modena, Italy.
Palmieri B; Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia, Modena, Italy; Second Opinion Medical Network, Modena, Italy.

Vaccine ; 38(48): 7581-7584, 2020 11 10.

Article in English | MEDLINE | ID: covidwho-845859

ABSTRACT

ABSTRACT

Today, Coronavirus Disease 2019 (COVID-19) is a global public health emergency and vaccination measures to counter its diffusion are deemed necessary. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiological agent of the disease, unleashes a T-helper 2 immune response in those patients requiring intensive care. Here, we illustrate the immunological mechanism to train the immune system towards a more effective and less symptomatic T-helper 1 immune response, to be exploited against SARS-CoV-2.

Subject(s)

BCG Vaccine/administration & dosage; Bacterial Vaccines/administration & dosage; Betacoronavirus/immunology; Coronavirus Infections/prevention & control; Immunity, Innate/drug effects; Pandemics/prevention & control; Pneumonia, Viral/prevention & control; Propionibacteriaceae/immunology; Betacoronavirus/drug effects; Betacoronavirus/pathogenicity; COVID-19; COVID-19 Vaccines; Coronavirus Infections/epidemiology; Coronavirus Infections/immunology; Coronavirus Infections/virology; Corynebacterium; Humans; Immunization Schedule; Immunogenicity, Vaccine; Interleukins/genetics; Interleukins/immunology; Patient Safety; Pneumonia, Viral/epidemiology; Pneumonia, Viral/immunology; Pneumonia, Viral/virology; SARS-CoV-2; Th1 Cells/drug effects; Th1 Cells/immunology; Th1 Cells/virology; Th1-Th2 Balance/drug effects; Th2 Cells/drug effects; Th2 Cells/immunology; Th2 Cells/virology; Vaccination; Viral Vaccines/administration & dosage; Viral Vaccines/biosynthesis

Keywords

Bacillus Calmette-Guérin (BCG); Coronavirus Disease 2019 (COVID-19); Corynebacterium parvum (C. parvum); Cutibacterium acnes (C. acnes); Hyaluronic acid; Propionibacterium acnes (P. acnes); Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2); T helper 1 (T(h)1); T helper 2 (T(h)2); Vaccine; cluster of differentiation 44 (CD44)

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Propionibacteriaceae / Bacterial Vaccines / BCG Vaccine / Coronavirus Infections / Pandemics / Betacoronavirus / Immunity, Innate Type of study: Etiology study / Observational study Topics: Vaccines Limits: Humans Language: English Journal: Vaccine Year: 2020 Document Type: Article

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