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Treatment for COVID-19: An overview.
Stasi, Cristina; Fallani, Silvia; Voller, Fabio; Silvestri, Caterina.
  • Stasi C; Epidemiology Unit, Tuscany Regional Health Agency, Florence, Italy; Department of Experimental and Clinical Medicine, Careggi University Hospital, Florence, Italy. Electronic address: cristina.stasi@gmail.com.
  • Fallani S; Epidemiology Unit, Tuscany Regional Health Agency, Florence, Italy.
  • Voller F; Epidemiology Unit, Tuscany Regional Health Agency, Florence, Italy.
  • Silvestri C; Epidemiology Unit, Tuscany Regional Health Agency, Florence, Italy.
Eur J Pharmacol ; 889: 173644, 2020 Dec 15.
Article in English | MEDLINE | ID: covidwho-846252
ABSTRACT
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by coronavirus-2 (SARS-CoV-2) that causes a severe acute respiratory syndrome, a characteristic hyperinflammatory response, vascular damage, microangiopathy, angiogenesis and widespread thrombosis. Four stages of COVID-19 have been identified the first stage is characterised by upper respiratory tract infection; the second by the onset of dyspnoea and pneumonia; the third by a worsening clinical scenario dominated by a cytokine storm and the consequent hyperinflammatory state; and the fourth by death or recovery. Currently, no treatment can act specifically against the SARS-CoV-2 infection. Based on the pathological features and different clinical phases of COVID-19, particularly in patients with moderate to severe COVID-19, the classes of drugs used are antiviral agents, inflammation inhibitors/antirheumatic drugs, low molecular weight heparins, plasma, and hyperimmune immunoglobulins. During this emergency period of the COVID-19 outbreak, clinical researchers are using and testing a variety of possible treatments. Based on these premises, this review aims to discuss the most updated pharmacological treatments to effectively act against the SARS-CoV-2 infection and support researchers and clinicians in relation to any current and future developments in curing COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Drug Treatment Type of study: Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Eur J Pharmacol Year: 2020 Document Type: Article