Structural Insight Into the Viral 3C-Like Protease Inhibitors: Comparative SAR/QSAR Approaches
Viral Proteases and Their Inhibitors
; 2020.
Article
in English
| PMC | ID: covidwho-848641
ABSTRACT
Severe acute respiratory syndrome (SARS), caused by SARS-coronavirus (SARS-CoV), is a dreadful infection worldwide having economic and medical importance and a global threat for health. It was turned into an epidemic in South China followed by a chain of infections across three generations. A number of pathogeneses in human may occur due to the virus. This infection has not been taken into account before the SARS outbreak, and still it is a neglected one. Therefore, there is an urgent need to develop small molecule antivirals to combat the SARS-CoV. No vaccines are available till date though a number of SARS-CoV 3C-like and 3C protease inhibitors were reported. In this chapter, quantitative structure–activity relationship technique is used for development of anti-SARS and anti-HRV drugs and outcome discussed in details. This approach may be a useful strategy to design novel and potential anti-SARS drugs to combat these dreadful viral diseases. FAU - Adhikari, Nilanjan
Full text:
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Collection:
Databases of international organizations
Database:
PMC
Language:
English
Journal:
Viral Proteases and Their Inhibitors
Year:
2020
Document Type:
Article
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