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COVID-19, myocardial edema and dexamethasone.
Rafiee, Moezedin Javad; Babaki Fard, Faranak; Friedrich, Matthias G.
  • Rafiee MJ; Research Institute, McGill University Health Centre, Montreal, QC, Canada.
  • Babaki Fard F; Faculty of Medicine, University of Montreal, Montreal, QC, Canada.
  • Friedrich MG; Cardiovascular Imaging, Depts. of Medicine and Diagnostic Radiology, McGill University Health Centre, Montreal, QC, Canada.
Med Hypotheses ; 145: 110307, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-850291
ABSTRACT
Severe acute respiratory syndrome corona virus 2(SARS-CoV-2), the cause of coronavirus disease- 2019 (COVID-19) after emerging in china in late 2019 is spreading rapidly across the world. The most common cause of death in patient with COVID-19 is the rapid progression of acute respiratory distress syndrome (ARDS) shortly after the beginning of dyspnea and hypoxemia. Patients with severe COVID-19 may also develop acute cardiac, kidney and liver injury that are associated with poor prognosis and can lead to high mortality rate. Numerous randomized trials are ongoing to find an effective, safe and widely available treatment. Remdisivir is the only FDA -approved antiviral agent for treatment of severe COVID-19. Glucocorticoids (GCs) have been used for treatment of cytokine storm syndrome and respiratory failure in hospitalized patient with severe covid-19. One of the therapeutic effects of GCs is stability of vascular endothelial barrier and decreasing tissue edema. In our opinion, the decreasing vascular permeability effect of glucocorticoids in the injured myocardium might has an important additional factor in reducing mortality in severe, hospitalized COVID-19 patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dexamethasone / Edema / COVID-19 / COVID-19 Drug Treatment / Myocardium Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.110307

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Dexamethasone / Edema / COVID-19 / COVID-19 Drug Treatment / Myocardium Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Topics: Long Covid Limits: Humans Country/Region as subject: Asia Language: English Journal: Med Hypotheses Year: 2020 Document Type: Article Affiliation country: J.mehy.2020.110307