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Risk factors for severe disease in patients admitted with COVID-19 to a hospital in London, England: a retrospective cohort study.
Goodall, J W; Reed, T A N; Ardissino, M; Bassett, P; Whittington, A M; Cohen, D L; Vaid, N.
  • Goodall JW; Department of Infection, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.
  • Reed TAN; Department of Acute Medicine, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.
  • Ardissino M; Department of Infection, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.
  • Bassett P; Statsconsultancy Ltd., London, UK.
  • Whittington AM; Department of Infection, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.
  • Cohen DL; Department of Acute Medicine, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.
  • Vaid N; Department of Acute Medicine, Northwick Park Hospital, London North West University Healthcare NHS Trust, London, UK.
Epidemiol Infect ; 148: e251, 2020 10 13.
Article in English | MEDLINE | ID: covidwho-851182
ABSTRACT
COVID-19 has caused a major global pandemic and necessitated unprecedented public health restrictions in almost every country. Understanding risk factors for severe disease in hospitalised patients is critical as the pandemic progresses. This observational cohort study aimed to characterise the independent associations between the clinical outcomes of hospitalised patients and their demographics, comorbidities, blood tests and bedside observations. All patients admitted to Northwick Park Hospital, London, UK between 12 March and 15 April 2020 with COVID-19 were retrospectively identified. The primary outcome was death. Associations were explored using Cox proportional hazards modelling. The study included 981 patients. The mortality rate was 36.0%. Age (adjusted hazard ratio (aHR) 1.53), respiratory disease (aHR 1.37), immunosuppression (aHR 2.23), respiratory rate (aHR 1.28), hypoxia (aHR 1.36), Glasgow Coma Scale <15 (aHR 1.92), urea (aHR 2.67), alkaline phosphatase (aHR 2.53), C-reactive protein (aHR 1.15), lactate (aHR 2.67), platelet count (aHR 0.77) and infiltrates on chest radiograph (aHR 1.89) were all associated with mortality. These important data will aid clinical risk stratification and provide direction for further research.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2020 Document Type: Article Affiliation country: S0950268820002472

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: Europa Language: English Journal: Epidemiol Infect Journal subject: Communicable Diseases / Epidemiology Year: 2020 Document Type: Article Affiliation country: S0950268820002472